G5173
Garcinol
≥95%
别名:
(1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione, Camboginol
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所有图片(1)
About This Item
经验公式（希尔记法）:
C38H50O6
CAS号:
分子量:
602.80
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
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方案
≥95%
表单
powder
颜色
yellow
溶解性
>5 mg/mL
储存温度
−20°C
SMILES字符串
C\C(C)=C\C[C@@H](C[C@@]12C[C@@H](C\C=C(\C)C)C(C)(C)[C@@](C\C=C(/C)C)(C(=O)C(=C1O)C(=O)c3ccc(O)c(O)c3)C2=O)C(C)=C
InChI
1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-40,42H,7,13,15,18,20-21H2,1-6,8-10H3/t27-,28+,37+,38-/m0/s1
InChI key
QDKLRKZQSOQWJQ-SMDXAGPFSA-N
生化/生理作用
Garcinol is a HAT (histone acetyltransferase) inhibitor. Garcinol is anti-inflammatory and anti-carcinogenic. Histone acetyltransferases provide opposing enzymatic mechanisms for chromatin remodeling and epigenetic control of gene expression. HATs are involved in regulation of transformation, transcription, differentiation, apoptosis, embryonic development and oncogenesis. IC50 p300 = 7 mM; IC50 PCAF = 5 mM (similar to anacardic acid). Garcinol is highly toxic compared to LTK-14, and does not discriminate between p300 and PCAF.
Garcinol is a HAT (histone acetyltransferase) inhibitor; anti-inflammatory; anti-carcinogenic.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Antonius J N M Bastiaansen et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1902-1910 (2013-06-22)
Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP-associated
Subhash Padhye et al.
Journal of hematology & oncology, 2, 38-38 (2009-09-04)
Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have
Meng-Shih Weng et al.
Journal of agricultural and food chemistry, 59(3), 1031-1040 (2011-01-11)
Garcinol is a polyisoprenylated benzophenone derivative found in Garcinia indica fruit rind and other species. The potential antioxidative and neuroprotective effects of garcinol in rat cortical astrocyte were demonstrated in our laboratory recently. Here, the effects of garcinol on the
Stephanie A Maddox et al.
PloS one, 8(1), e54463-e54463 (2013-01-26)
The study of the cellular and molecular mechanisms underlying the consolidation and reconsolidation of traumatic fear memories has progressed rapidly in recent years, yet few compounds have emerged that are readily useful in a clinical setting for the treatment of
Sahdeo Prasad et al.
Molecular cancer therapeutics, 9(4), 856-868 (2010-04-08)
Whether garcinol, the active component of Garcinia indica, can modulate the sensitivity of cancer cells to TRAIL, a cytokine currently in phase II clinical trial, was investigated. We found that garcinol potentiated TRAIL-induced apoptosis of cancer cells as indicated by
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