G5170
半乳糖凝集素-3 人
recombinant, expressed in E. coli, lyophilized powder
别名:
CBP 35, Carbohydrate-binding protein 35, Gal-3, Galactose-specific lectin 3, Galactoside-binding protein
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关于此项目
Form:
lyophilized powder
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
Quality Level
form
lyophilized powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... LGALS3(3958)
General description
半乳凝素-3蛋白包括一个N-末端弹性域和一个C-末端碳水化合物识别域 (CRD)。它位于人染色体14q22.3。半乳凝素-3在感觉神经元、免疫内皮和上皮细胞中表达。
Application
人半乳凝素-3已被用于：
- 测试其与量子点上N-乙酰乳糖胺涂层的相互作用
- 优化未凝聚和凝聚鸡红细胞（RBC）中Gal3诱发红细胞凝聚的测定
- 多个硬化症患者血清样品的Gal-3结合检测
Biochem/physiol Actions
半乳凝素-3（Gal3）具有抗细胞凋亡性质，并介导癌细胞与内皮的粘附。乳糖会抑制半乳凝素-3的活性。高水平的Gal3与心血管疾病有关，并且是心力衰竭相关纤维化和炎症中的潜在生物标志物。Gal3与多种生物活动有关，包括从分化到宿主防御和免疫调节。Gal3基因缺失与肾功能异常（如肾病）有关联。它与视网膜病和非酒精性脂肪性肝病（NAFLD）的发病机制有关。
半乳糖凝集素-3与癌症的细胞凋亡抑制和进展有关，也是炎症的一种调节因子。研究发现半乳糖凝集素-3的表达与结肠癌、肝癌和甲状腺癌的致瘤性和转移呈正相关。
Physical form
将产物是从水中冻干的，每μg的半乳糖凝集素-3含有2 μg的乳糖作为稳定剂。
Other Notes
半乳糖凝集素-3是动物凝集素家族的一员，可选择性地结合β-g半乳糖苷残基。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
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相关内容
Instructions
Rui Dong et al.
International journal of molecular medicine, 41(2), 599-614 (2017-12-06)
Galectin-3 is a member of the galectin family, which are β‑galactoside‑binding lectins with ≥1 evolutionary conserved carbohydrate‑recognition domain. It binds proteins in a carbohydrate‑dependent and ‑independent manner. Galectin‑3 is predominantly located in the cytoplasm; however, it shuttles into the nucleus
Wei Zhao et al.
Analytical biochemistry, 571, 37-39 (2019-02-25)
Hemagglutination inhibition (HAI) assay is a simple method quantifying relative binding activities of glycan-lectin interactions. Currently, interpretation of HAI data remains a manual task depending on visual observation. In this study we developed a digital data reading method for HAI
Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions
Yang Y, et al.
Tetrahedron, 68(35), 7148-7154 (2012)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| G5170-100UG | 04061833384862 |