G5170
半乳糖凝集素-3 人
recombinant, expressed in E. coli, lyophilized powder
别名:
CBP 35, Carbohydrate-binding protein 35, Gal-3, Galactose-specific lectin 3, Galactoside-binding protein
产品名称
半乳糖凝集素-3 人, recombinant, expressed in E. coli, lyophilized powder
recombinant
expressed in E. coli
form
lyophilized powder
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... LGALS3(3958)
Application
人半乳凝素-3已被用于：
- 测试其与量子点上N-乙酰乳糖胺涂层的相互作用
- 优化未凝聚和凝聚鸡红细胞（RBC）中Gal3诱发红细胞凝聚的测定
- 多个硬化症患者血清样品的Gal-3结合检测
Biochem/physiol Actions
半乳凝素-3（Gal3）具有抗细胞凋亡性质，并介导癌细胞与内皮的粘附。乳糖会抑制半乳凝素-3的活性。高水平的Gal3与心血管疾病有关，并且是心力衰竭相关纤维化和炎症中的潜在生物标志物。Gal3与多种生物活动有关，包括从分化到宿主防御和免疫调节。Gal3基因缺失与肾功能异常（如肾病）有关联。它与视网膜病和非酒精性脂肪性肝病（NAFLD）的发病机制有关。
半乳糖凝集素-3与癌症的细胞凋亡抑制和进展有关，也是炎症的一种调节因子。研究发现半乳糖凝集素-3的表达与结肠癌、肝癌和甲状腺癌的致瘤性和转移呈正相关。
General description
半乳凝素-3蛋白包括一个N-末端弹性域和一个C-末端碳水化合物识别域 (CRD)。它位于人染色体14q22.3。半乳凝素-3在感觉神经元、免疫内皮和上皮细胞中表达。
Other Notes
半乳糖凝集素-3是动物凝集素家族的一员，可选择性地结合β-g半乳糖苷残基。
Physical form
将产物是从水中冻干的，每μg的半乳糖凝集素-3含有2 μg的乳糖作为稳定剂。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Matthew R Kovak et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 72(4), 403-412 (2014-05-28)
Galectin-3 is a β-galactoside binding protein with immunomodulatory properties and exerts its extracellular functions via interactions with glycoconjugate ligands. Therefore, to elucidate the function of galectin-3, binding ligands in human seminal plasma were investigated. Galectin-3 binding proteins were isolated from
Andrea Robotti et al.
Electrophoresis, 31(17), 2882-2893 (2010-08-18)
Plasma acute-phase proteins (APPs) glyco-isoforms are important biomarkers of inflammatory processes such as those occurring in multiple sclerosis (MS). Specific analysis of these proteins is often hampered by sample biochemical complexity. The aim of our study was to set up
Giuseppe Pugliese et al.
Glycobiology, 25(2), 136-150 (2014-10-12)
Galectin-3 has been increasingly recognized as an important modulator of several biological functions, by interacting with several molecules inside and outside the cell, and an emerging player in numerous disease conditions. Galectin-3 exerts various and sometimes contrasting effects according to
Synthesis of multivalent N-acetyl lactosamine modified quantum dots for the study of carbohydrate and galectin-3 interactions
Yang Y, et al.
Tetrahedron, 68(35), 7148-7154 (2012)
Wei Zhao et al.
Analytical biochemistry, 571, 37-39 (2019-02-25)
Hemagglutination inhibition (HAI) assay is a simple method quantifying relative binding activities of glycan-lectin interactions. Currently, interpretation of HAI data remains a manual task depending on visual observation. In this study we developed a digital data reading method for HAI
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