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Merck
CN

G5013

G 418 二硫酸盐

potency: ≥720 μg per mg (dried basis)

别名:

抗生素G418

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关于此项目

经验公式(希尔记法):
C20H40N4O10 · 2H2SO4
化学文摘社编号:
分子量:
692.71
MDL number:
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
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产品名称

G 418 二硫酸盐, potency: ≥720 μg per mg (dried basis)

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O

InChI

1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1

InChI key

UHEPSJJJMTWUCP-NKCAIAFTSA-N

form

powder

potency

≥720 μg per mg (dried basis)

color

white to off-white

solubility

H2O: 100 mg/mL

antibiotic activity spectrum

Gram-negative bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

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Disclaimer

本品在2-8°C可稳定储存三年。储备水溶液可在-20至-70 °C稳定储存约6个月。

General description

化学结构:氨基糖苷类

Preparation Note

G418粉末可以100 mg/mL溶于水。

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yoshie Tange et al.
PLoS genetics, 8(6), e1002776-e1002776 (2012-06-28)
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Matthias Geissbuehler et al.
Advances in experimental medicine and biology, 737, 263-268 (2012-01-20)
Alexandra L Petrache et al.
Frontiers in cellular neuroscience, 14, 568194-568194 (2020-12-03)
Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer's disease (AD), continually fail clinical trials. We investigated whether this was due to the change in the
Shijia Yu et al.
Frontiers in cellular neuroscience, 14, 193-193 (2020-08-08)
Cerebral ischemic stroke is regarded as one of the most serious diseases in the human central nervous system. The secondary ischemia and reperfusion (I/R) injury increased the difficulty of treatment. Moreover, the latent molecular regulating mechanism in I/R injury is
Terezie Imrichova et al.
Aging, 11(17), 7206-7235 (2019-09-08)
Diverse stress insults trigger interactions of PML with nucleolus, however, the function of these PML nucleolar associations (PNAs) remains unclear. Here we show that during induction of DNA damage-induced senescence in human non-cancerous cells, PML accumulates at the nucleolar periphery

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