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Merck
CN
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文件

安全信息

G4918

Sigma-Aldrich

庆大霉素 硫酸酯

meets EP, USP testing specifications

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别名:
庆大霉素 硫酸盐
CAS号:
1405-41-0
EC 号:
215-778-9
MDL编号:
MFCD00270181
UNSPSC代码:
51101500
eCl@ss:
42020823
PubChem化学物质编号:
329799932
NACRES:
NA.76

Agency

meets EP testing specifications
meets USP testing specifications

质量水平

200

形式

powder

旋光性

[α]/D 107 to 121°

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

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相关类别

一般描述

Chemical structure: aminoglycoside

应用

Gentamicin sulfate, a broad-spectrum antibiotic, used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L.

生化/生理作用

作用机制：庆大大霉素通过和30S核糖亚基结合，引起密码子误读，阻碍肽酰转移酶从供体位点转移到受体位点。庆大霉素通过它与外膜的结合来发挥它对铜绿假单胞菌的杀菌作用，它在外膜上置换天然阳离子，使膜不稳定，并在细胞表面形成孔。

抗菌谱：包括革兰氏阴性和革兰氏阳性细菌，包括对于四环素、氯霉素、卡那霉素和粘菌素，某些特定假单胞菌菌株，变形杆菌属，Staphylococcus 和 Streptococcus 的抗性。

组分

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.

注意

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

危险分类

Skin Sens. 1

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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