促性腺激素 来源于孕马血清

Equine Gonadotropin, Pregnant Mares′ Serum (PMS-G) is used in conjunction with Human chorionic gonadotropin (hCG, Product No. C 8554) to superovulate female mice. PMS-G is used to promote egg follicle maturation by mimicking the effects of follicle stimulating hormone(FSH). For optimal egg production, hCG is injected 42 to 48 hours post PMS-G injection and is required for follicle rupture. Reconstitute 1 vial of PMS-G with 1 ml of 0.9% Sodium Chloride Solution (Product No. S 8776) to give a final concentration of 50 IU/ml. Intraperitoneally inject 0.1 ml into each animal. Product is qualified for use in mouse embryo preparation.

双链糖蛋白激素；可促进卵泡生长和黄体形成。

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.