推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
分子量
antigen ~50 kDa
种属反应性
mouse, rat, human (predicted), bovine (predicted), chicken (predicted)
技术
immunohistochemistry: suitable using rat brain sections
western blot: 1:400-1:1,000 using rat brain membranes
UniProt登记号
储存温度
−20°C
基因信息
human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
一般描述
GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.
免疫原
peptide corresponding to amino acids 28-43 of rat GABA(A) receptor α1 subunit.
应用
Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit is suitable for detection of GABA-A α1 subunit by immunohistochemistry using rat brain sections and by immunoblotting at a working dilution of 1:400-1:1000 using rat brain membranes.
生化/生理作用
The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α1 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.
外形
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
制备说明
Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
含少量动物源组分生物产品
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