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Merck
CN

G4401

鸟苷 5′-二磷酸-β- L -岩藻糖 钠盐

≥85%, powder

别名:

6-脱氧-β- L -半乳吡喃糖基鸟苷 5′-二磷酸, GDP-Fuc, GDP-海藻糖

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关于此项目

经验公式(希尔记法):
C16H23N5Na2O15P2
化学文摘社编号:
分子量:
633.31
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
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产品名称

鸟苷 5′-二磷酸-β- L -岩藻糖 钠盐, ≥85%

Quality Level

assay

≥85%

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CC1OC(OP(O)(=O)OP(O)(=O)OCC2OC(C(O)C2O)n3cnc4C(=O)N=C(N)Nc34)C(O)C(O)C1O

InChI

1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)

InChI key

LQEBEXMHBLQMDB-UHFFFAOYSA-N

General description

岩藻糖基转移酶底物
鸟苷5′-二磷酸-β-L-岩藻糖(GDP-岩藻糖)是存在于细菌和人类中的一种核苷酸糖,也是岩藻糖基转移酶的底物。

Application

鸟苷5′-二磷酸-β-L-岩藻糖钠盐可用作岩藻糖基转移酶VII(FTVII)反应缓冲液组分,用于鼠脂肪组织来源间充质干细胞(AMSC)的胞外岩藻糖基化。它已用于微生物凝集试验和凝集抑制试验。
鸟苷5′-二磷酸-β-L-岩藻糖钠盐已用于微生物凝集试验和凝集抑制试验。


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Glycobiology and Glycoproteomics Brochure


Stephen T B Lau et al.
Journal of the American Chemical Society, 130(51), 17593-17602 (2008-12-05)
L-fucose, 6-deoxy-L-galactose, is a key component of many important glycoconjugates including the blood group antigens and the Lewis(X) ligands. The biosynthesis of GDP-L-fucose begins with the action of a dehydratase that converts GDP-D-mannose into GDP-4-keto-6-deoxy-mannose. The enzyme GDP-fucose synthase, GFS
Qiang Yang et al.
The Journal of biological chemistry, 292(36), 14796-14803 (2017-07-22)
The mammalian α1,6-fucosyltransferase (FUT8) catalyzes the core fucosylation of
Laure Barbé et al.
Scientific reports, 8(1), 12961-12961 (2018-08-30)
Human strains of rotavirus A (RVAs) recognize fucosylated glycans belonging to histo-blood group antigens (HBGAs) through their spike protein VP8*. Lack of these ligands due to genetic polymorphisms is associated with resistance to gastroenteritis caused by P[8] genotype RVAs. With



全球贸易项目编号

货号GTIN
G4401-2MG04061832924052
G4401-1MG04061826674925
G4401-5MG04061833631096