SMILES string
N3(C(CCC3)C(=O)NC(CCC(=O)N)C(=O)O)C(=O)C(NC(=O)C1N(CCC1)C(=O)C(N)Cc2ccc(cc2)O)CCC(=O)N
InChI key
HZWWPUTXBJEENE-UHFFFAOYSA-N
InChI
1S/C29H41N7O9/c30-18(15-16-5-7-17(37)8-6-16)27(42)35-13-1-3-21(35)25(40)33-19(9-11-23(31)38)28(43)36-14-2-4-22(36)26(41)34-20(29(44)45)10-12-24(32)39/h5-8,18-22,37H,1-4,9-15,30H2,(H2,31,38)(H2,32,39)(H,33,40)(H,34,41)(H,44,45)
biological source
wheat
form
powder
technique(s)
enzyme immunoassay: suitable
flow cytometry: suitable
Quality Level
Gene Information
wheat ... Gli-Z1(100682397), pqn5(543384)
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Analysis Note
粗品；来自小麦面筋
Application
小麦来源麦醇溶蛋白用于：
- 胃蛋白酶-胰蛋白酶消化，研究体外麦醇溶蛋白挑战对无麸质饮食（GFD）乳糜泻（CD）患者活检组织的影响
- 制备麦醇溶蛋白，用于抗麦醇溶蛋白抗体测定
- 作为标准品，通过流式细胞仪，定量皮克级的麦醇溶蛋白
Biochem/physiol Actions
麦醇溶蛋白包含富含谷氨酰胺和脯氨酸的单体蛋白质家族，其占小麦籽粒总蛋白质含量的 40-50%。 醇溶性麦醇溶蛋白与不溶于醇的谷蛋白聚集形成谷蛋白，这是小麦面团的结构和性质的原因。 麦醇溶蛋白还参与乳糜泻的发病机制，乳糜泻是一种自身免疫性疾病，其中人白细胞抗原 DQ2 和 DQ8 将胶质肽递呈至 T 细胞亚群，诱导促炎细胞因子的释放，进而诱导肠黏膜基质的降解和细胞死亡。B 细胞也被刺激产生谷蛋白特异性和转谷氨酰胺酶 2 (TG2) 特异性抗体，后者可能是由麦醇溶蛋白肽与 TG2 共价结合的呈递所致。
General description
谷蛋白由醇溶蛋白和谷蛋白两个醇溶蛋白家族组成。醇溶蛋白是一种疏水性很强的糖蛋白，溶解性极差。醇溶蛋白可进一步细分为 α-醇溶蛋白类，γ-醇溶蛋白和 ω-醇溶蛋白（基于其在低 pH 下电泳时的迁移率顺序。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
此项目有
Sanja Petronijevic et al.
European journal of oral sciences, 128(1), 27-36 (2020-02-23)
Previously we detected increased levels of IgA to the enamel matrix protein amelogenin in children with untreated coeliac disease (CeD). The biological impact of autoantibodies to amelogenin may depend on which part of the amelogenin (epitopes) they bind. Sera or
L J Chartrand et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 157(5), 527-533 (1997-09-19)
To test the effectiveness of serologic antigliadin antibody (AGA) testing in predicting celiac disease in children. Prospective clinical assessment. Hôpital Sainte-Justine, montreal. A total of 176 children with possible celiac disease who were referred for duodenal biopsy between January 1992
THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge
Bondar C, et al.
European Journal of Human Genetics, 22(3), 358-362 (2013)
Elma Mj Salentijn et al.
BMC genomics, 14, 905-905 (2013-12-21)
Wheat gluten is important for the industrial quality of bread wheat (Triticum aestivum L.) and durum wheat (T. turgidum L.). Gluten proteins are also the source of immunogenic peptides that can trigger a T cell reaction in celiac disease (CD)
K Sivasegaran et al.
International journal of cosmetic science, 29(2), 103-110 (2008-05-21)
Pre-screening of cosmetic ingredients is vital for consumer safety. Previous in vivo techniques, such as the Draize test, have proved to be unreliable in predicting ocular irritancy and therefore there is a need for alternate testing methodologies. One such test
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