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G2536

Sigma-Aldrich

更昔洛韦

≥99% (HPLC), powder, viral DNA elongation inhibitor

别名:

2-氨基-1,9-二氢-9-[[2-羟基-1-(羟甲基)乙氧基]甲基]-6H-嘌呤-6-酮, 9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤, DHPG

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About This Item

经验公式（希尔记法）:
C9H13N5O4
CAS号:
82410-32-0
分子量:
255.23
MDL编号:
MFCD00870588
UNSPSC代码:
12352200
PubChem化学物质编号:
24278453
NACRES:
NA.77

产品名称

更昔洛韦, ≥99% (HPLC), powder

质量水平

300

方案

≥99% (HPLC)

表单

powder

颜色

white

溶解性

0.1 M HCl: 10 mg/mL

ε (消光系数)

12.0 at 256 nm at 1 mM

抗生素抗菌谱

viruses

作用机制

DNA synthesis | interferes

创始人

Roche

储存温度

2-8°C

SMILES字符串

NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1

InChI

1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)

InChI key

IRSCQMHQWWYFCW-UHFFFAOYSA-N

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一般描述

化学结构：核苷

应用

分子生物学中，当需要对目的基因进行同源重组时，更昔洛韦可用于选择随机重组事件。

生化/生理作用

更昔洛韦是一种前药核苷类似物，通过磷酸化激活。可用于癌症研究中基因治疗的研究。
在编码胸苷激酶的病毒自杀基因表达后，无毒前药转化成磷酸化的活性类似物并掺入复制真核细胞的DNA中，导致恶性分裂细胞死亡。在G2-M检查点不可逆转地阻滞细胞周期。研究了间隙连接在更昔洛韦旁观者效应中的参与情况。更昔洛韦用于研究端粒丢失 和评估病毒对抗病毒治疗的敏感性。

特点和优势

该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
该化合物由 Roche开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录， 请单击此处。

制备说明

更昔洛韦可溶于0.1 M HCl(10 mg/ml)、DMSO(5 mg/ml)、水(2 mg/ml)、热甲醇和乙醇(<1 mg/ml)。
本品应在2-8℃下干燥保存，在此条件下可稳定保存3年。
Ganciclovir is tested for solubility in 0.1M HCl at 10 mg/mL. The compound is also soluble in DMSO at 5 mg/mL.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340,H361fd

危险分类

Muta. 1B - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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分析证书(COA)

Lot/Batch Number
0000365343
0000327960
0000327960
0000365343
0000287003

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访问文档库

Zhanguo Gao et al.
Biomolecules, 11(10) (2021-10-24)
Duchenne muscular dystrophy (DMD), caused by the loss of dystrophin, remains incurable. Reduction in muscle regeneration with DMD is associated with the accumulation of fibroadipogenic progenitors (FAPs) differentiating into myofibroblasts and leading to a buildup of the collagenous tissue aggravating
Sunwen Chou
Reviews in medical virology, 18(4), 233-246 (2008-04-03)
Mutations in the human CMV UL97 kinase gene are a major mechanism of viral resistance to two anti-CMV drugs, ganciclovir (GCV) and maribavir (MBV). GCV, the most widely used and established therapy for CMV, is a substrate for the UL97
C N Sprung et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(12), 6781-6786 (1999-06-09)
The addition of new telomeres to the ends of broken chromosomes, termed chromosome healing, has been extensively studied in unicellular organisms; however, its role in the mammalian cell response to double-strand breaks is unknown. A system for analysis of chromosome
L Z Rubsam et al.
Cancer research, 59(3), 669-675 (1999-02-11)
The ability of herpes simplex virus type 1 thymidine kinase (HSV-TK)-expressing cells incubated with ganciclovir (GCV) to induce cytotoxicity in neighboring HSV-TK-negative (bystander) cells has been well documented. Although it has been suggested that this bystander cell killing occurs through
Julie Cates Scott et al.
Therapeutic drug monitoring, 26(1), 68-77 (2004-01-30)
The authors use a previously published decision-making algorithm to address the role of clinical pharmacokinetic monitoring of ganciclovir, the drug of choice for prophylaxis and treatment of cytomegalovirus (CMV) in solid organ transplant recipients. Ganciclovir pharmacokinetics have been studied in
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