G2501
L-谷氨酸脱氢酶 来源于牛肝脏
Type I, ammonium sulfate suspension, ≥40 units/mg protein
别名:
L -GLDH, L -谷氨酸盐：NAD[P]+ 氧化还原酶（脱氨）, 谷氨酸脱氢酶 来源于牛肝脏
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-848-4
MDL number:
Specific activity:
≥40 units/mg protein
type
Type I
form
ammonium sulfate suspension
specific activity
≥40 units/mg protein
mol wt
310-350 kDa
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
cow ... GLUD1(281785)
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Biochem/physiol Actions
L-谷氨酸脱氢酶可催化谷氨酸转化成α-酮戊二酸。
这种酶的哺乳动物形式，包括这种牛形式，可以使用 NADP (H) 或 NAD (H) 作为辅酶。 L -谷氨酸脱氢酶在哺乳动物代谢中起着独特角色。该酶催化的逆向反应是氨与 α-淀粉结合的唯一途径。-α 的碳原子-因此，羧酸是哺乳动物中从头合成氨基酸的唯一来源。
牛酶的特点有三组属性：
L-谷氨酸脱氢酶催化谷氨酸转化为 α-酮戊二酸 。
牛酶的特点有三组属性：
- 具有可逆的浓度依赖性结合，产生较高分子量形式。
- 形成紧密的酶-还原型辅酶-底物三元复合物，其解离速率调节稳态反应速率。
- 表现出各种各样的影响，从结合的任何编号核苷酸修饰。
L-谷氨酸脱氢酶催化谷氨酸转化为 α-酮戊二酸 。
Physical form
2.0 M (NH4)2SO4 溶液混悬液
Analysis Note
双缩脲法测蛋白
Other Notes
在25℃、pH 7.3、铵离子存在的条件下，一单位酶每分钟可将1.0 μmM α-酮戊二酸还原成 L-谷氨酸。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
Hyperinsulinism and hyperammonaemia syndrome and severe myoclonic epilepsy of infancy.
F Pérez Errazquin et al.
Neurologia (Barcelona, Spain), 26(4), 248-252 (2010-12-18)
Mehran Karimi et al.
Seminars in thrombosis and hemostasis, 35(4), 426-438 (2009-07-15)
Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. By cross-linking fibrin chains and alpha (2) plasmin inhibitor
Charles A Stanley
Neurochemistry international, 59(4), 465-472 (2010-12-07)
Glutamate dehydrogenase (GDH) has recently been shown to be involved in two genetic disorders of hyperinsulinemic hypoglycemia in children. These include the hyperinsulinism/hyperammonemia syndrome caused by dominant activating mutations of GLUD1 which interfere with inhibitory regulation by GTP and hyperinsulinism
Ioannis Zaganas et al.
Neurochemistry international, 55(1-3), 52-63 (2009-05-12)
In all mammals, glutamate dehydrogenase (GDH), an enzyme central to the metabolism of glutamate, is encoded by a single gene (GLUD1 in humans) which is expressed widely (housekeeping). Humans and other primates also possess a second gene, GLUD2, which encodes
Konstantinos Kanavouras et al.
Journal of neurochemistry, 109 Suppl 1, 167-173 (2009-05-07)
Glutamate dehydrogenase (GDH) in human exists in GLUD1 and GLUD2 gene-encoded isoforms (hGDH1 and hGDH2, respectively), differing in their regulation and tissue expression pattern. Whereas hGDH1 is subject to GTP control, hGDH2 uses for its regulation, a novel molecular mechanism
商品
Instructions for working with enzymes supplied as ammonium sulfate suspensions
以硫酸铵悬浮液形式提供的酶的使用指南
相关内容
QC Methods
Product Information Sheet
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