类型
Type I
质量水平
形式
ammonium sulfate suspension
比活
≥40 units/mg protein
分子量
310-350 kDa
UniProt登记号
储存温度
2-8°C
基因信息
cow ... GLUD1(281785)
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生化/生理作用
L-谷氨酸脱氢酶可催化谷氨酸转化成α-酮戊二酸。
这种酶的哺乳动物形式,包括这种牛形式,可以使用 NADP (H) 或 NAD (H) 作为辅酶。 L -谷氨酸脱氢酶在哺乳动物代谢中起着独特角色。该酶催化的逆向反应是氨与 α-淀粉结合的唯一途径。-α 的碳原子-因此,羧酸是哺乳动物中从头合成氨基酸的唯一来源。
牛酶的特点有三组属性:
L-谷氨酸脱氢酶催化谷氨酸转化为 α-酮戊二酸 。
牛酶的特点有三组属性:
- 具有可逆的浓度依赖性结合,产生较高分子量形式。
- 形成紧密的酶-还原型辅酶-底物三元复合物,其解离速率调节稳态反应速率。
- 表现出各种各样的影响,从结合的任何编号核苷酸修饰。
L-谷氨酸脱氢酶催化谷氨酸转化为 α-酮戊二酸 。
单位定义
在25℃、pH 7.3、铵离子存在的条件下,一单位酶每分钟可将1.0 μmM α-酮戊二酸还原成 L-谷氨酸。
外形
2.0 M (NH4)2SO4 溶液混悬液
分析说明
双缩脲法测蛋白
底物
产品编号
说明
价格
警示用语:
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Neurotoxicity research, 21(1), 117-127 (2011-11-01)
Glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to α-ketoglutarate and ammonia. High levels of GDH activity is found in mammalian liver, kidney, brain, and pancreas. In the liver, GDH reaction appears to be close-to-equilibrium, providing the appropriate ratio
The European journal of neuroscience, 32(2), 191-197 (2010-07-22)
Several C1q family members, especially the Cbln and C1q-like subfamilies, are highly and predominantly expressed in the central nervous system. Cbln1, a member of the Cbln subfamily, plays two unique roles at parallel fiber (PF)-Purkinje cell synapses in the cerebellum:
Journal of pediatric endocrinology & metabolism : JPEM, 24(7-8), 573-577 (2011-09-22)
Hyperinsulinism-hyperammonemia syndrome (HI/HA) (OMIM 606762), the second most common form of congenital hyperinsulinism (CHI) is associated with activating missense mutations in the GLUD1 gene, which encodes the mitochondrial matrix enzyme, glutamate dehydrogenase (GDH). Patients present with recurrent symptomatic postprandial hypoglycemia
Hyperinsulinism and hyperammonaemia syndrome and severe myoclonic epilepsy of infancy.
Neurologia (Barcelona, Spain), 26(4), 248-252 (2010-12-18)
Seminars in thrombosis and hemostasis, 35(4), 426-438 (2009-07-15)
Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. By cross-linking fibrin chains and alpha (2) plasmin inhibitor
商品
以硫酸铵悬浮液形式提供的酶的使用指南
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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