类型
Type I
质量水平
表单
ammonium sulfate suspension
比活
≥40 units/mg protein
分子量
310-350 kDa
UniProt登记号
储存温度
2-8°C
基因信息
cow ... GLUD1(281785)
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生化/生理作用
L-谷氨酸脱氢酶可催化谷氨酸转化成α-酮戊二酸。
这种酶的哺乳动物形式,包括这种牛形式,可以使用 NADP (H) 或 NAD (H) 作为辅酶。 L -谷氨酸脱氢酶在哺乳动物代谢中起着独特角色。该酶催化的逆向反应是氨与 α-淀粉结合的唯一途径。-α 的碳原子-因此,羧酸是哺乳动物中从头合成氨基酸的唯一来源。
牛酶的特点有三组属性:
L-谷氨酸脱氢酶催化谷氨酸转化为 α-酮戊二酸 。
牛酶的特点有三组属性:
- 具有可逆的浓度依赖性结合,产生较高分子量形式。
- 形成紧密的酶-还原型辅酶-底物三元复合物,其解离速率调节稳态反应速率。
- 表现出各种各样的影响,从结合的任何编号核苷酸修饰。
L-谷氨酸脱氢酶催化谷氨酸转化为 α-酮戊二酸 。
外形
2.0 M (NH4)2SO4 溶液混悬液
分析说明
双缩脲法测蛋白
其他说明
在25℃、pH 7.3、铵离子存在的条件下,一单位酶每分钟可将1.0 μmM α-酮戊二酸还原成 L-谷氨酸。
警示用语:
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
Mehran Karimi et al.
Seminars in thrombosis and hemostasis, 35(4), 426-438 (2009-07-15)
Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. By cross-linking fibrin chains and alpha (2) plasmin inhibitor
Hyperinsulinism and hyperammonaemia syndrome and severe myoclonic epilepsy of infancy.
F Pérez Errazquin et al.
Neurologia (Barcelona, Spain), 26(4), 248-252 (2010-12-18)
Konstantinos Kanavouras et al.
Journal of neurochemistry, 109 Suppl 1, 167-173 (2009-05-07)
Glutamate dehydrogenase (GDH) in human exists in GLUD1 and GLUD2 gene-encoded isoforms (hGDH1 and hGDH2, respectively), differing in their regulation and tissue expression pattern. Whereas hGDH1 is subject to GTP control, hGDH2 uses for its regulation, a novel molecular mechanism
Charles A Stanley
Neurochemistry international, 59(4), 465-472 (2010-12-07)
Glutamate dehydrogenase (GDH) has recently been shown to be involved in two genetic disorders of hyperinsulinemic hypoglycemia in children. These include the hyperinsulinism/hyperammonemia syndrome caused by dominant activating mutations of GLUD1 which interfere with inhibitory regulation by GTP and hyperinsulinism
Ioannis Zaganas et al.
Neurochemistry international, 55(1-3), 52-63 (2009-05-12)
In all mammals, glutamate dehydrogenase (GDH), an enzyme central to the metabolism of glutamate, is encoded by a single gene (GLUD1 in humans) which is expressed widely (housekeeping). Humans and other primates also possess a second gene, GLUD2, which encodes
商品
Instructions for working with enzymes supplied as ammonium sulfate suspensions
以硫酸铵悬浮液形式提供的酶的使用指南
相关内容
Product Information Sheet
QC Methods
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