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安全信息

G2392

Sigma-Aldrich

Disialoganglioside GD1a from bovine brain

≥95% (TLC), lyophilized powder

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别名:
Ganglioside GD1a, disialo from bovine brain
CAS号:
12707-58-3
Beilstein:
6228822
MDL编号:
MFCD00130960
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

200

检测方案

≥95% (TLC)

形式

lyophilized powder

溶解性

DMSO: soluble

储存温度

−20°C

InChI

1S/C86H152N4O39.2Na/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-51(100)50(90-60(105)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2)46-118-80-69(111)67(109)72(57(43-94)120-80)123-82-71(113)78(129-86(84(116)117)39-53(102)62(88-48(4)98)77(128-86)65(107)55(104)41-92)74(59(45-96)122-82)124-79-63(89-49(5)99)75(66(108)56(42-93)119-79)125-81-70(112)68(110)73(58(44-95)121-81)126-85(83(114)115)38-52(101)61(87-47(3)97)76(127-85)64(106)54(103)40-91;;/h34,36,50-59,61-82,91-96,100-104,106-113H,6-33,35,37-46H2,1-5H3,(H,87,97)(H,88,98)(H,89,99)(H,90,105)(H,114,115)(H,116,117);;/q;2*+1/p-2/b36-34+;;/t50-,51+,52?,53?,54-,55-,56?,57?,58?,59?,61+,62+,63?,64-,65-,66?,67?,68?,69?,70?,71?,72?,73?,74?,75?,76?,77?,78?,79?,80?,81?,82?,85?,86?;;/m0../s1

InChI key

CWLDKTAXQZEVQN-CUEXFKMESA-L

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相关类别

Amino Acid Sequence

Cer-Glc-Gal(NeuAc)-GalNAc-Gal-NeuAc

一般描述

Gangliosides are in the neuronal cell membranes and endoplasmic reticulum. They consist of a sialylated polysaccharide chain linked via β-glycosidic linkage to ceramide. They are also located in body fluids and plasma. GD1a consists of a neutral tetrasaccharide core with one sialic acid on the internal galactose and another sialic acid on the non-reducing terminal galactose.

应用

Disialoganglioside GD1a from bovine brain has been used:
  • as a receptor for the detection of murine norovirus-1 (MNV-1) by RT-PCR
  • as a glycolipid to study the interaction between protein human endogenous retrovirus W family pHERV-W ENV and glycolipids by enzyme-linked immunosorbent assay (ELISA)
  • as a reference standard to analyze the ganglioside signatures of prostate cancer cells by high-performance liquid chromatography

生化/生理作用

Gangliosides are involved in cellular functions such as the differentiation of neurons, formation of axons, synapses, cell proliferation, differentiation, adhesion, and cell death. In addition, gangliosides form microdomains on the outer surface of the cell membranes that are involved in signal transduction and help in the formation of dendrites. Gangliosides act as Ca2+ binding co-factors during synaptic transmission.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Go Ogawa et al.
Journal of neuroimmunology, 254(1-2), 141-145 (2012-09-25)
Antibodies to a ganglioside complex consisting of GM1 and GalNAc-GD1a (GM1/GalNAc-GD1a) are found in sera from patients with Guillain-Barré syndrome (GBS). To elucidate the clinical significance of anti-GM1/GalNAc-GD1a antibodies in GBS, clinical features of 58 GBS patients with IgG anti-GM1/GalNAc-GD1a
K F Meiri et al.
Journal of neurochemistry, 62(1), 291-299 (1994-01-01)
Phosphorylation of the nervous system-specific protein GAP-43 in growth cones in vivo increases as the growth cones near their targets, at a time when the gangliosides GM1 and GD1a are being accumulated in the growth cone membrane, thus raising the
Recurrent GBS with GD1a anti-ganglioside antibodies.
Pınar Yalinay Dikmen et al.
Journal of the peripheral nervous system : JPNS, 17(1), 135-137 (2012-04-03)
Critical studies on binding-based RT-PCR detection of infectious Noroviruses
Dan L, et al.
Journal of Virological Methods, 153-159 (2011)
Biosynthesis of the major brain gangliosides GD1a and GT1b
Elizabeth R S, et al.
Glycobiology, 22(10), 1289?1301-1289?1301 (2012)
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