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Merck
CN
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安全信息

G211150

Sigma-Aldrich

DMT-2′O-Methyl-rG(ib) Phosphoramidite

configured for (ÄKTA® and OligoPilot®)

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别名:
DMT-2′-O-甲基-rG(ib)酰胺
经验公式（希尔记法）:
C45H56N7O9P
CAS号:
150780-67-9
分子量:
869.94
MDL编号:
MFCD00792625
UNSPSC代码:
12352200
PubChem化学物质编号:
329799866
NACRES:
NA.51

生物来源

non-animal source (no BSE/TSE risk)

质量水平

300

产品线

Proligo Reagents

检测方案

≥99% (31P-NMR)
≥99.0% (reversed phase HPLC)

形式

powder

技术

oligo synthesis: suitable

杂质

≤0.1% single unspecified Impurity (reversed phase HPLC)
≤0.3% mG2 (reversed phase HPLC, Hydrolysate)
≤0.3% mG3 (reversed phase HPLC, DMT-rG(ib)me)
≤0.3% water content (Karl Fischer)
≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
≤1.0% mG1 (reversed phase HPLC, DMT-rG(ib)me-DMT)
≤3% residual Solvent content

颜色

white to off-white

λ

conforms (UV/VIS Identity)

适用性

conforms to structure for H-NMR
conforms to structure for LC-MS

相容性

configured for (ÄKTA® and OligoPilot®)

核苷分析

base: guanosine
base protecting group: isobutyryl
2' protecting group: methyl
5' protecting group: DMT
deprotection: standard

储存温度

2-8°C

SMILES字符串

CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c3ccc(OC)cc3)c4ccc(OC)cc4)O[C@H]1n5cnc6C(=O)NC(NC(=O)C(C)C)=Nc56

InChI

1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9)38(61-62(59-25-13-24-46)52(29(3)4)30(5)6)36(60-43)26-58-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/m1/s1

InChI key

IRRDHRZUOZNWDJ-MLLDKZSOSA-N

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相关类别

一般描述

Proligo′s 2′O-Methyl RNA monomers are compatible with fast deprotectionschemes that are based on the application of aliphatic amines, such asmethylamine. The adenosine and guanosine monomers are protected bythe standard benzoyl (bz) and isobutyryl (ib) groups.2′O-Methyl RNA is a nucleic acid analog that is characterized by theexceptional hybridization properties that it imparts with complimentaryDNA or RNA, as well as increased stability against enzymatic degradationcompared to natural nucleic acids.The unique combination of properties of 2′O-Methyl RNA had foundwidespread use in the fields of:
  • Diagnostic probes
  • Aptamer and ribozyme development
  • Mixed 2′O-Methyl-RNA/DNA antisense molecules
Key Features:
  • High yield of crude oligonucleotides
  • Compatible with DNA synthesis
  • Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
  • Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
  • Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradationDMT-2′O-Methyl-rG(ib)
Phosphoramidite is configured for ÄKTA® Synthesizers.

法律信息

OligoPilot is a registered trademark of Cytiva
ÄKTA is a registered trademark of Cytiva

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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