质量水平
检测方案
≥97%
形式
powder
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1
InChI
1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
InChI key
LLJJDLHGZUOMQP-UHFFFAOYSA-N
应用
GO6983已作为蛋白激酶C(PKC)抑制剂,用以研究其对核输入的影响。它还用作Fc培养基中的补充剂,以在丝裂霉素C处理过的小鼠胚胎成纤维细胞(MEF)上培养小鼠胚胎干(mES)细胞。
生化/生理作用
蛋白激酶C(PKC)抑制剂选择性抑制几种 PKC 同工酶(PKCα和PKCβ的IC50=7nM;PKCγ 为6 nM;PKCδ 为10 nM;PKCζ 为60nM),但不抑制PKCμ(IC50=20 mM)。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
Nature, 552(7684), 239-239 (2017)
Nature, 504(7479), 282-286 (2013-11-01)
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2
The Journal of biological chemistry, 285(7), 4883-4895 (2009-11-18)
Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and
iScience, 25(2), 103751-103751 (2022-02-05)
Modulation of the neuronal K+/Cl- cotransporter 2 (KCC2) activity, which mediates Cl- export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an essential component of membrane insertion machinery. Using
Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder
Theranostics, 9(3), 646-646 (2019)
商品
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
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