跳转至内容
Merck
CN

G1918

Sigma-Aldrich

Gö 6983

≥97%

别名:

3-[1- [3-(二甲氨基)丙基]-5-甲氧基-1H-吲哚-3-基] -4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C26H26N4O3
分子量:
442.51
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥97%

形式

powder

溶解性

DMSO: 10 mg/mL, clear

储存温度

−20°C

SMILES字符串

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

应用

GO6983已作为蛋白激酶C(PKC)抑制剂,用以研究其对核输入的影响。它还用作Fc培养基中的补充剂,以在丝裂霉素C处理过的小鼠胚胎成纤维细胞(MEF)上培养小鼠胚胎干(mES)细胞。

生化/生理作用

蛋白激酶C(PKC)抑制剂选择性抑制几种 PKC 同工酶(PKCα和PKCβ的IC50=7nM;PKCγ 为6 nM;PKCδ 为10 nM;PKCζ 为60nM),但不抑制PKCμ(IC50=20 mM)。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
Shahbazi MN, et al.
Nature, 552(7684), 239-239 (2017)
Ohad Gafni et al.
Nature, 504(7479), 282-286 (2013-11-01)
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2
Shirley E Bradley et al.
The Journal of biological chemistry, 285(7), 4883-4895 (2009-11-18)
Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and
Hila Asraf et al.
iScience, 25(2), 103751-103751 (2022-02-05)
Modulation of the neuronal K+/Cl- cotransporter 2 (KCC2) activity, which mediates Cl- export, is critical to neuronal function. Here, we demonstrate that KCC2 interacts with the SNARE protein synaptosome-associated protein 23, SNAP23, an essential component of membrane insertion machinery. Using
Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder
Yun CY, et al.
Theranostics, 9(3), 646-646 (2019)

商品

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门