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If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

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G1918

Sigma-Aldrich

Gö 6983

≥97%

别名:

3-[1- [3-（二甲氨基）丙基]-5-甲氧基-1H-吲哚-3-基] -4-（1H-吲哚-3-基）-1H-吡咯-2，5-二酮

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500 μG
CN¥1,642.51
1 MG
CN¥1,885.28

CN¥1,642.51

预计发货时间April 27, 2025详情

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500 μG
CN¥1,642.51
1 MG
CN¥1,885.28

About This Item

经验公式（希尔记法）:
C26H26N4O3
CAS号:
133053-19-7
分子量:
442.51
MDL编号:
MFCD04040031
UNSPSC代码:
12352200
PubChem化学物质编号:
24894916
NACRES:
NA.77

CN¥1,642.51

预计发货时间April 27, 2025详情

获取大包装报价

质量水平

100

方案

≥97%

表单

powder

溶解性

DMSO: 10 mg/mL, clear

储存温度

−20°C

SMILES字符串

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

InChI key

LLJJDLHGZUOMQP-UHFFFAOYSA-N

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此商品
272832728427312
Crimp top microvial, requiring a 8 mm seal volume 0.7 mL, amber glass vial, O.D. × H 7 mm × 40 mm , flat bottom, pkg of 100 ea

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Crimp top microvial, requiring a 8 mm seal

Crimp top microvial, requiring a 8 mm seal volume 0.2 mL, clear glass vial (tapered bottom), O.D. × H 6 mm × 32 mm, pkg of 200 ea

27283

Crimp top microvial, requiring a 8 mm seal

Crimp top microvial, requiring a 8 mm seal volume 0.2 mL, clear glass vial (tapered bottom), O.D. × H 6 mm × 32 mm, pkg of 1000 ea

27284

Crimp top microvial, requiring a 8 mm seal

Crimp top microvial, requiring a 8 mm seal volume 0.6 mL, amber glass vial, O.D. × H 7 mm × 30 mm , conical, pkg of 200 ea

27312

Crimp top microvial, requiring a 8 mm seal

fitting

thread for 8 mm

fitting

thread for 8 mm (crimp top)

fitting

thread for 8 mm (crimp top), thread for 8 mm crmip

fitting

thread for 8 mm

feature

closure type crimp top vial

feature

closure type crimp top vial

feature

closure type crimp top vial

feature

closure type crimp top vial

volume

0.7 mL

volume

0.2 mL

volume

0.2 mL

volume

0.6 mL

material

amber glass vial

material

clear glass vial (tapered bottom)

material

clear glass vial (tapered bottom)

material

amber glass vial

packaging

pkg of 100 ea

packaging

pkg of 200 ea

packaging

pkg of 1000 ea

packaging

pkg of 200 ea

O.D. × H

7 mm × 40 mm , flat bottom

O.D. × H

6 mm × 32 mm

O.D. × H

6 mm × 32 mm

O.D. × H

7 mm × 30 mm , conical

应用

GO6983已作为蛋白激酶C（PKC）抑制剂，用以研究其对核输入的影响。[1]它还用作Fc培养基中的补充剂，以在丝裂霉素C处理过的小鼠胚胎成纤维细胞（MEF）上培养小鼠胚胎干（mES）细胞。[2]

生化/生理作用

蛋白激酶C（PKC）抑制剂选择性抑制几种 PKC 同工酶（PKCα和PKCβ的IC50=7nM；PKCγ 为6 nM；PKCδ 为10 nM；PKCζ 为60nM），但不抑制PKCμ（IC50=20 mM）。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000216275
    0000216268
    0000183858
    0000216268
    0000216275

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    Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
    Shahbazi MN, et al.
    Nature, 552(7684), 239-239 (2017)
    Ohad Gafni et al.
    Nature, 504(7479), 282-286 (2013-11-01)
    Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2
    Li-Chun Lisa Tsai et al.
    The Journal of biological chemistry, 290(36), 21845-21856 (2015-07-19)
    Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP)
    Debasree Dutta et al.
    Stem cells (Dayton, Ohio), 29(4), 618-628 (2011-02-11)
    The intricate molecular mechanisms that regulate ESC pluripotency are incompletely understood. Prior research indicated that activation of the Janus kinase-signal transducer and activator of transcription (STAT3) pathway or inhibition of extracellular signal-regulated kinase/glycogen synthase kinase 3 (ERK/GSK3) signaling maintains mouse
    Shirley E Bradley et al.
    The Journal of biological chemistry, 285(7), 4883-4895 (2009-11-18)
    Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and
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