所有图片(1)
About This Item
经验公式（希尔记法）:
C18H31N7O5
CAS号:
分子量:
425.48
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
质量水平
方案
≥95% (HPLC)
储存温度
−20°C
SMILES字符串
NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
InChI
1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
InChI key
WXPZDDCNKXMOMC-AVGNSLFASA-N
基因信息
human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)
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Amino Acid Sequence
Gly-Pro-Arg-Pro
一般描述
Gly-Pro-Arg-Pro是一种模拟纤维蛋白α链的N-末端Gly-Pro-Arg区域的肽。
应用
Gly-Pro-Arg-Pro（GPRP）已被用于形成由GPRP和来自血纤维蛋白原γ链的30kDa C末端片段（rFbgγC30）组成的晶体，其中，rFbgγC30是在 酵母中克隆和表达的。
生化/生理作用
Gly-Pro-Arg-Pro肽能够抑制纤维蛋白聚合的早期阶段。即使是存在EGTA（乙二醇-双（β-氨基乙基醚）-N,N,N′,N′-四乙酸）的情况下，该肽的酰胺衍生物也能抑制纤溶酶对纤维蛋白原和片段D的降解。
Gly-Pro-Arg-Pro（GPRP）能够增加游离凝血酶。因此，它可用于制备凝血酶脱粒的（thrombin-degranulated）血小板，其有助于研究血小板反应。
抑制纤维蛋白聚合。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Ramesh Ramapanicker et al.
Bioconjugate chemistry, 24(1), 17-25 (2012-11-16)
The synthetic tetrapeptide GPRP based on the amino-terminal GPR sequence of the fibrin α-chain binds the D-dimer protein with a dissociation constant K(D) of 25 μM. The D-dimer protein, a well-known biomarker for thrombosis, contains two cross-linked D fragments from
U Haddeland et al.
Thrombosis and haemostasis, 75(2), 326-331 (1996-02-01)
The present paper shows that conformationally changed fibrinogen can expose the sites A alpha-(148-160) and gamma-(312-324) involved in stimulation of the tissue-type plasminogen activator (t-PA)-catalysed plasminogen activation. The exposure of the stimulating sites was determined by ELISA using mABs directed
Katharina Neubauer et al.
Cytoskeleton (Hoboken, N.J.), 76(1), 131-136 (2018-07-19)
Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder associated with episodic, recurrent, and painful neuropathies affecting the nerves of the brachial plexus. In this study, we report on a family of Lebanese descent with HNA onset in early childhood.
L Pasalic et al.
Journal of thrombosis and haemostasis : JTH, 16(6), 1198-1210 (2018-03-24)
Essentials Procoagulant platelets can be detected using GSAO in human whole blood. Stable coronary artery disease is associated with a heightened procoagulant platelet response. Agonist-induced procoagulant platelet response is not inhibited by aspirin alone. Collagen plus thrombin induced procoagulant platelet
Elena Monzón Manzano et al.
British journal of haematology, 189(5), 943-953 (2020-01-17)
Multifactorial mechanisms leading to diminished platelet counts in immune thrombocytopaenia (ITP) might condition the ability of patients with ITP to respond to treatments. Examining their platelet and immune features, we aimed to detect singular characteristics of patients with ITP who
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