G136
Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt
solid
别名:
Sp-Cyclic 3′5′-hydrogen phosphorothioate guanosine triethylammonium salt, Sp-cGMPS triethylammonium salt
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所有图片(1)
About This Item
经验公式（希尔记法）:
C10H12N5O6PS · C6H15N
CAS号:
分子量:
462.46
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
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表单
solid
质量水平
颜色
white
溶解性
H2O: 5 mg/mL
运输
dry ice
储存温度
−20°C
SMILES字符串
CCN(CC)CC.NC1=Nc2c(ncn2[C@@H]3O[C@@H]4CO[P@](O)(=S)O[C@H]4[C@H]3O)C(=O)N1
InChI
1S/C10H12N5O6PS.C6H15N/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(20-9)1-19-22(18,23)21-6;1-4-7(5-2)6-3/h2-3,5-6,9,16H,1H2,(H,18,23)(H3,11,13,14,17);4-6H2,1-3H3/t3-,5-,6-,9-,22+;/m1./s1
InChI key
SBVIQYPGQBMDDI-GWHKBMFWSA-N
生化/生理作用
Sp-cGMPS is a metabolically resistant activator of cGMP-dependent protein kinases.
其他说明
Sp-Diastereomer of guanosine 3′,5′-cyclic monophosphorothioate.
注意
吸湿
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
S L Archer et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(16), 7583-7587 (1994-08-02)
Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes relaxation is unknown. This study tested the hypothesis that activation of Ca-sensitive K (KCa) channels, mediated by
E Butt et al.
FEBS letters, 263(1), 47-50 (1990-04-09)
The activation of the cGMP-dependent protein kinase and cAMP-dependent protein kinase by the diastereomers of guanosine 3',5'-monophosphorothioate, (Sp)-cGMPS and (Rp)-cGMPS, and 8-chloroguanosine 3',5'-monophosphorothioate, (Sp)-8-Cl-cGMPS and (Rp)-8-Cl-cGMPS, was investigated using the peptide Kemptide as substrate. The (Sp)-diastereomers, which have an axial
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