G136
Sp-Guanosine 3′,5′-cyclic monophosphorothioate triethylammonium salt
solid
别名:
Sp-Cyclic 3′5′-hydrogen phosphorothioate guanosine triethylammonium salt, Sp-cGMPS triethylammonium salt
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关于此项目
经验公式（希尔记法）:
C10H12N5O6PS · C6H15N
化学文摘社编号:
分子量:
462.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
InChI key
SBVIQYPGQBMDDI-GWHKBMFWSA-N
SMILES string
CCN(CC)CC.NC1=Nc2c(ncn2[C@@H]3O[C@@H]4CO[P@](O)(=S)O[C@H]4[C@H]3O)C(=O)N1
InChI
1S/C10H12N5O6PS.C6H15N/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(20-9)1-19-22(18,23)21-6;1-4-7(5-2)6-3/h2-3,5-6,9,16H,1H2,(H,18,23)(H3,11,13,14,17);4-6H2,1-3H3/t3-,5-,6-,9-,22+;/m1./s1
form
solid
color
white
solubility
H2O: 5 mg/mL
shipped in
dry ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Sp-cGMPS is a metabolically resistant activator of cGMP-dependent protein kinases.
Other Notes
Sp-Diastereomer of guanosine 3′,5′-cyclic monophosphorothioate.
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S L Archer et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(16), 7583-7587 (1994-08-02)
Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes relaxation is unknown. This study tested the hypothesis that activation of Ca-sensitive K (KCa) channels, mediated by
E Butt et al.
FEBS letters, 263(1), 47-50 (1990-04-09)
The activation of the cGMP-dependent protein kinase and cAMP-dependent protein kinase by the diastereomers of guanosine 3',5'-monophosphorothioate, (Sp)-cGMPS and (Rp)-cGMPS, and 8-chloroguanosine 3',5'-monophosphorothioate, (Sp)-8-Cl-cGMPS and (Rp)-8-Cl-cGMPS, was investigated using the peptide Kemptide as substrate. The (Sp)-diastereomers, which have an axial
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