所有图片(1)
别名:
12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Go 6976
经验公式（希尔记法）:
C24H18N4O
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检测方案
≥98% (HPLC)
形式
powder
颜色
white
溶解性
DMSO: >5 mg/mL
储存温度
−20°C
SMILES字符串
Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13
InChI
1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChI key
VWVYILCFSYNJHF-UHFFFAOYSA-N
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应用
Gö 6976 has been used:
- as an inhibitor of protein kinase C (PKC) in mammalian cell lines
- as a PKCμ inhibitor in oocytes
- as a PKC-α to test its effect on phosphorylation of protein kinase-B (Akt) and extracellular-signal-regulated kinase (ERK) levels
生化/生理作用
Go¨6976 also acts as an effective inhibitor of protein kinase C isoform (PKCμ) and abolishes phorbol ester mediated potentiation in oocytes. It inhibits PKC α and β selectively. Go-6976 may also inhibit S6-kinase 1.
Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC50=2.3 nM) and β1 (IC50=6.2 nM) isozymes.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
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