推荐产品
质量水平
检测方案
≥98% (HPLC)
储存条件
protect from light
under inert gas
溶解性
methanol: 1 mg/mL, clear, colorless
应用
metabolomics
vitamins, nutraceuticals, and natural products
运输
dry ice
储存温度
−20°C
SMILES字符串
CCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1
InChI
1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
InChI key
NLDDIKRKFXEWBK-AWEZNQCLSA-N
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一般描述
[6]-姜酚与细胞凋亡、细胞周期调节、细胞毒性活性和血管生成抑制有关。它防止血清素释放和血小板聚集。姜酚具有免疫调节、抗凋亡、抗高血糖、降血脂和止吐药的特性。
应用
[6]-姜酚已用于:
- 研究其对瞬时受体电位(TRP)通道的影响
- 研究其对非酒精性脂肪性肝炎实验模型的影响
- 确定其对微粒体前列腺素E2合酶1 (mPGES-1)、糖原合酶激酶3β (GSK-3β)和A549细胞株中β-连环蛋白通路的影响
- 分析6-姜稀酚(6-SG)对db/db小鼠糖尿病肾病(DN)的影响
生化/生理作用
存在于生姜 (Zingiber officinale) 中的具有抗氧化活性的生物活性化合物,可用作抗炎剂和抗肿瘤剂。6-姜酚通过巨噬细胞下调促炎细胞因子的释放。已证明它可通过阻断经佛波酯刺激的小鼠皮肤中 p38 MAP 激酶和 NF-κB 的活化来抑制 COX-2 的表达。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
[6]-Gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis
Phytomedicine, 22(4), 452-461 (2015)
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97, 633-641 (2017-11-05)
The prevalence of type 2 diabetes mellitus has been increasing worldwide and more than two thirds of the patients may develop diabetic nephropathy (DN). However, the efficiency of existing approaches on DN progression is limited. 6-Shogaol (6-SG), a major dehydrated
Biological properties of 6-gingerol: a brief review.
Natural Product Communications, 9(7), 1027-1030 (2014)
Molecules (Basel, Switzerland), 20(6), 10280-10297 (2015-06-06)
Numerous bioactive compounds have cytotoxic properties towards cancer cells. However, most studies have used single compounds when bioactives may target different pathways and exert greater cytotoxic effects when used in combination. Therefore, the objective of this study was to determine
Journal of natural medicines (2019-06-10)
Our previous study reported that combined treatment of γ-tocotrienol with 6-gingerol showed promising anticancer effects by synergistically inhibiting proliferation of human colorectal cancer cell lines. This study aimed to identify and elucidate molecular mechanisms involved in the suppression of SW837
商品
Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.
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