G0549
Corosolic acid from Lagerstroemia speciosa
≥98% (HPLC)
别名:
Corosolic acid, (2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid, 2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol
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关于此项目
经验公式（希尔记法）:
C30H48O4
化学文摘社编号:
分子量:
472.70
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
Corosolic acid from Lagerstroemia speciosa, ≥98% (HPLC)
InChI
1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
SMILES string
O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1
InChI key
HFGSQOYIOKBQOW-ZSDYHTTISA-N
assay
≥98% (HPLC)
form
powder
solubility
methanol: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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Application
Corosolic acid from Lagerstroemia speciosa has been used to study the inhibiting activity of ursolic acid and its derivative against colon cancer cells by causing degradation of β-catenins.
Biochem/physiol Actions
Triterpene phytochemical found in medicinal herbal extracts. Possesses antiatherosclerotic, antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral and antineoplastic activities.
Corosolic acid from Lagerstroemia speciose shows a variety of biological activities such as anti-proliferation, apoptosis, and anti-carcinogenic. It exhibits an inhibiting effect on the post-challenge plasma glucose levels in humans. Corosolic acid, due to its ability to improve glucose metabolism, has been touted to be used in the management of Type-2 Diabetes. It improves hypertension, oxidative stress, and inflammation, thereby being a potential candidate to be used against atherosclerosis-related diseases.
General description
Corosolic acid from Lagerstroemia speciosa is a pentacyclic triterpenoid found in a variety of plants, such as apples, basil, bilberries, cranberries, and prunes. It is a natural derivative of ursolic acid.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Myung Sun Lee et al.
Biological & pharmaceutical bulletin, 33(6), 931-937 (2010-06-05)
Overexpression/amplification of human epidermal growth factor receptor (HER)2/neu (erbB-2) oncogene plays a causal role in carcinogenesis and correlates with a poor clinical prognosis. However, little is known about HER2 in gastric cancer. In this study, we explored the pharmacological activities
Yu Yamaguchi et al.
Life sciences, 79(26), 2474-2479 (2006-09-09)
Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities. The aim of this study was to determine the effects of CRA on metabolic risk factors including obesity, hypertension, hyperinsulinemia, hyperglycemia, and hyperlipidemia
Toshihiro Miura et al.
Biological & pharmaceutical bulletin, 29(3), 585-587 (2006-03-02)
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA
Joo-Hyun Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 67, 87-95 (2014-02-26)
Ursolic acid (UA) and corosolic acid (CA), naturally occurring pentacyclic triterpene acids, exhibit antiproliferative activities against various cancer cells, but a clear chemopreventive mechanism of these triterpenoids in colon cancer cells remains to be answered. Here we used a cell-based
Yanfeng Xu et al.
Cancer letters, 284(2), 229-237 (2009-05-22)
We investigated the response of human cervix adenocarcinoma HeLa cells to Corosolic acid (CRA) treatment. Our results showed that CRA significantly inhibited cell viability in both a dose- and a time-dependent manner. CRA treatment induced S cell-cycle arrest and caused
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