G0419
GR 55562 dihydrobromide
>97% (HPLC), powder
别名:
3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide
InChI
1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H
InChI key
NUDSRNNZTVHCKY-UHFFFAOYSA-N
description
Store tightly sealed with desiccant.
assay
>97% (HPLC)
form
powder
color
light yellow
solubility
H2O: ~12 mg/mL (with mixing)
storage temp.
2-8°C
Biochem/physiol Actions
5-HT1B/5-HT1D serotonin receptor antagonist
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14(3), 217-225 (2004-04-02)
The present study was aimed at finding out whether 5-HT(1B) receptors located in the ventral tegmental area (VTA) played a role in the locomotor hyperactivity induced by a single dose of cocaine and in the sensitization evoked by repeated exposure
Zheng-Ming Ding et al.
Psychopharmacology, 204(3), 381-390 (2009-01-24)
Previous studies indicated that ethanol could be self-infused into the posterior ventral tegmental area (p-VTA) and that activation of local serotonin-3 (5-HT(3)) receptors was involved. 5-HT(1B) and 5-HT(2A) receptors are involved in the effects of 5-HT and ethanol on VTA
Iwona Papla et al.
Polish journal of pharmacology, 54(4), 351-357 (2003-01-14)
Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study
E Przegaliński et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 53(3), 383-394 (2002-10-09)
The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted
Ji-Hyun Kim et al.
Pharmacology, biochemistry, and behavior, 87(1), 41-47 (2007-05-05)
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h
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