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安全信息

G0282

Sigma-Aldrich

粒细胞巨噬细胞集落刺激因子 来源于小鼠

GM-CSF, from mouse, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

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别名:
GM-CSF
MDL编号:
MFCD00241918
UNSPSC代码:
12352202
NACRES:
NA.77

生物来源

mouse

质量水平

200

重组

expressed in E. coli

检测方案

≥97% (SDS-PAGE)

形式

lyophilized powder

效能

≤0.2 ng/mL EC50 (corresponds to ≥5 × 106 units/mg)

质量

endotoxin tested

分子量

~15 kDa (125 amino acids including N-terminal methionine)

包装

pkg of 5 and 50 μg

储存条件

avoid repeated freeze/thaw cycles

技术

cell culture | mammalian: suitable

杂质

≤1 EU/mg

颜色

white

溶解性

water: soluble, clear, colorless

UniProt登记号

P01587

储存温度

−20°C

基因信息

mouse ... CSF2(12981) , Csf2(12981)

相关类别

生化/生理作用

粒细胞-巨噬细胞集落刺激因子（GM-CSF）是粒细胞、巨噬细胞和嗜酸性粒细胞系的生长和分化因子。GM-CSF 在极低浓度下刺激多能祖细胞集落形成，是造血祖细胞直至成熟的所有分裂中必不可少的存活和增殖因子。它也刺激一些上皮细胞和破骨细胞的生长。GM-CSF 由多种细胞类型（单核细胞、内皮细胞、T 细胞、成纤维细胞、有丝分裂原刺激的 B 细胞和 LPS 刺激的巨噬细胞）产生。GM-CSF 是一种单链糖蛋白，含有 128 个氨基酸，具有保守的二硫键。人和鼠 GM-CSF 的序列同源性约为 54%，生物活性无交叉反应。

外形

从 10 mM 乙酸 + 250 μg BSA 中冻干。

分析说明

使用小鼠 FDP-1 细胞在培养物中检测了小鼠 GM-CSF 的 EC50 活性。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

含少量动物源组分生物产品
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M A Guthridge et al.
Stem cells (Dayton, Ohio), 16(5), 301-313 (1998-10-10)
The process of ligand binding leading to receptor activation is an ordered and sequential one. High-affinity binding of GM-CSF, interleukin 3 (IL-3), and IL-5 to their receptors induces a number of key events at the cell surface and within the
M H Heim
Journal of receptor and signal transduction research, 19(1-4), 75-120 (1999-03-11)
The Jak-STAT pathway was originally discovered through the study of interferon induced intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and growth factors have been found to activate Jaks and STATs. Jaks (Janus Kinases) are a unique class
Vasiliki Kyrargyri et al.
Glia, 63(4), 549-566 (2014-10-10)
Microglia are CNS resident immune cells and a rich source of neuroactive mediators, but their contribution to physiological brain processes such as synaptic plasticity, learning, and memory is not fully understood. In this study, we used mice with partial depletion
A Kelso
Immunology and cell biology, 76(4), 300-317 (1998-09-02)
Cytokines participate in the induction and effector phases of all immune and inflammatory responses. They are therefore obvious tools and targets for strategies designed to promote, inhibit or redirect these responses. However, the complexity of the cytokine network has hindered
R C Skoda
Journal of receptor and signal transduction research, 19(1-4), 741-772 (1999-03-11)
The helical cytokines constitute a family of proteins with a common three-dimensional structure. They exert a wide variety of biological effects with a preference for the hematopoietic system. The effects of helical cytokines are mediated by cell surface receptors, which
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