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生物来源
sugar beets root
质量水平
偶联物
FITC conjugate
表单
powder
分子量
average mol wt 20,000
标记范围
0.003-0.020 mol FITC per mol glucose
颜色
yellow to dark yellow
溶解性
water: 25 mg/mL
储存温度
2-8°C
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一般描述
右旋糖酐是一种无水葡萄糖聚合物。由约 95% 的 α-D-(166) 键组成。其余 (163) 连接可解释右旋糖酐的分支。分支长度的冲突数据表明平均分支长度小于 3 个葡萄糖单位。然而，其他方法表明存在超过 50 个葡萄糖单位的分支。已发现天然右旋糖酐分子量 (MW) 在 900 万 ～5 亿范围内。较低分子量的右旋糖酐将表现出略少的分支，并且分子量分布范围更窄。分子量大于 10,000 的右旋糖酐表现得好像它们是高度支链。随着分子量的增加，葡聚糖分子的对称性增强。分子量为 2,000 至 10,000 的葡聚糖，表现出可膨胀弹簧圈的属性。在分子量低于 2000 时，右旋糖酐更呈棒状。采用以下一种或多种方法测定右旋糖酐的分子量：小角激光光散射法、分子排阻色谱法、铜络合-蒽酮试剂比色法测定还原糖含量和粘度。
应用
FITC-右旋糖酐作为荧光通量示踪化合物用于心血管、微循环、灌注、细胞单层和细胞膜渗透性研究，支持血流、膜损伤、血管引流和肾脏消除等过程的测量。小的 FITC-右旋糖酐也用于测量细胞内吞和细胞连接通透性等过程。荧光素-葡聚糖，20 kDa，可用于研究细胞过程，如内吞和渗透压。FITC-右旋糖酐-20 可用于研究内皮细胞或上皮细胞单层孔隙度、细胞层内顶端基底侧运动和细胞连接渗透性。FITC-右旋糖酐-20 可作为研究氢原子和胶原微棒等结构药物释放的模型化合物。
FITC-右旋糖酐利用显微荧光法广泛用于微循环和细胞渗透性研究。FITC-右旋糖酐已被用于研究植物细胞壁多孔性和毛细管渗透性。已证明血浆蛋白不与 FITC-右旋糖酐结合。
用异硫氰酸荧光素标记的葡聚糖可用于动物的灌注研究。
联系
类似于 FD-20，但由 Sigma 生产。
制备说明
Sigma 通常检测浓度等于或高于 25 mg/mL 的 FITC 葡聚糖在水中的溶解度。溶液应避光保存。在体内，FITC-右旋糖酐可稳定 24 小时以上。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Marcia Regina da Silva Pedrini et al.
Applied microbiology and biotechnology, 98(3), 1271-1280 (2013-12-10)
Internalization of hydrophilic molecules into yeast cytosol is required for different applications such as cell transformation or preservation of water soluble components by bioencapsulation. However, these molecules are not able to cross the plasma membrane and strategies have to be
Iris Metzmacher et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 67(2), 349-360 (2007-04-06)
A drug delivery system, named minirod, containing insoluble non-cross-linked collagen was prepared to investigate the release of model drug compounds. To characterise the complete drug release process properly, a mathematical model was developed. Previously, a mathematical model describing water penetration
Kaushik Parthasarathi
American journal of physiology. Lung cellular and molecular physiology, 303(1), L33-L42 (2012-05-09)
Acid aspiration, a common cause of acute lung injury, leads to alveolar edema. Increase in lung vascular permeability underlies this pathology. To define mechanisms, isolated rat lungs were perfused with autologous blood. Hydrochloric acid and rhodamine-dextran 70 kDa (RDx70) were
Damia Mawad et al.
International journal of pharmaceutics, 366(1-2), 31-37 (2008-09-24)
Injectable hydrogels have potential biomedical applications ranging from tissue fillers to drug delivery vehicles. This study focussed on evaluating the structure of poly(vinyl alcohol) (PVA) hydrogels of variable solid content and high molecular weight model drug release from the networks
Sunali Bhatnagar et al.
Journal of pharmaceutical sciences, 103(6), 1903-1912 (2014-04-11)
Ultrasound (US) exposure of soft tissues, such as the skin, has been shown to increase permeability, enhancing the passage of drug molecules via passive processes such as diffusion. However, US regimes have not been exploited to enhance active convective transport
相关内容
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.
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