所有图片(1)
About This Item
经验公式(希尔记法):
C22H29N3O3S2 · xC2HF3O2
CAS号:
分子量:
447.61 (free base basis)
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥95% (HPLC)
表单
film
储存条件
desiccated
溶解性
H2O: ≥2 mg/mL
运输
dry ice
储存温度
−70°C
SMILES字符串
OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2
InChI
1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
InChI key
GJEFFRDWFVSCOJ-PXPMWPIZSA-N
应用
法呢基转移酶抑制剂277(FTI-277)已被用于
- 在乳腺癌细胞系中抑制蛋白法呢基化。
- 骨髓分离的成人多系诱导细胞(MIAMI)中。
- 在与带有SV40基因细胞(COS-7)的起源中抑制CV-1中的法呢基转移酶。
生化/生理作用
可拮抗H和K-Ras致癌信号的强效(pM/nM)Ras CAAX拟肽。 法呢基转移酶(Ftase)抑制剂IC50 = 50 nM。
法呢基转移酶抑制剂277(FTI-277)可介导多发性骨髓瘤的细胞凋亡,并被认为是一种潜在的治疗剂。
包装
极易吸湿材料,与脱氧的MeOH一起包装在干燥的房间中,并抽走溶剂。与干燥剂一起储存。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
Bolick SCE, et al.
Leukemia, 17(2), 451-457 (2003)
Progerin expression disrupts critical adult stem cell functions involved in tissue repair
Pacheco LM, et al.
Aging (Albany. NY.), 6(12), 1049-1063 (2014)
Endothelial protective genes induced by statin is mimicked by FTI-277 and GGTI-298 drug combination-mediated ERK5 activation
Chu UB, et al.
Biochimica et Biophysica Acta, 1850(7), 1415-1425 (2015)
Daisuke Tsuji et al.
Biochemical and biophysical research communications, 556, 93-98 (2021-04-13)
Sepsis remains a leading cause of mortality in critically ill patients and is characterized by multi-organ dysfunction. Mitochondrial damage has been proposed to be involved in the pathophysiology of sepsis. In addition to metabolic impairments resulting from mitochondrial dysfunction, mitochondrial
Bingchen Han et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 30(2), 672-687 (2021-07-19)
Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung-resident fibroblasts to produce the C-C motif
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