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安全信息

F9765

Sigma-Aldrich

菲律宾菌素复合体 来源于菲律宾链霉菌

≥70% (UV)

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别名:
Filimarisin
CAS号:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77

生物来源

Streptomyces sp. (Streptomyces filipinensis)

质量水平

检测方案

≥70% (UV)

形式

powder

溶解性

methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow

抗生素抗菌谱

fungi

作用机制

cell membrane | interferes

储存温度

−20°C

InChI

1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1

InChI key

IMQSIXYSKPIGPD-YQRUMEKGSA-N

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一般描述

化学结构:大环内酯

应用

来自非律平链霉菌的非律平复合物已用作检测细胞中游离胆固醇的荧光探针。

生化/生理作用

菲律平是一种多烯大环内酯类抗生素和抗真菌药。抗真菌作用的机理尚不清楚,但可能是由于膜通透性改变所致。 非律平以形成膜孔的方向与含胆固醇的模型结晶相脂质双层结合,并与具有或没有胆固醇的液相双层结合。它既抑制蛋白(PrP)的内吞作用,又导致 PrP 从质膜释放。

其他说明

非律平包含 8 个异构体成分,其中非律平 III 是主要成分。

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象形图

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警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How should Product F9765, Filipin complex from Streptomyces filipinensis, be solubilized?

    This product has low solubility in aqueous buffers. It should initially be reconstituted in DMSO at 1 mg/mL and then diluted into saline or an aqueous buffer of choice.

  4. What is the stability of stock solutions Product F9765, Filipin complex from Streptomyces filipinensis?

    Solutions of filipin in aqueous or organic solvents are not considered to be stable and it is recommended that they be prepared fresh and not stored as stock solutions.

  5. What is the difference between Filipin products F9765 and F4767?

    The product F9765 consists of a filipin complex. It is composed of 8 isomeric components, of which filipin III is the major component in the complex. F4767 consists of filipin III alone and is considered to be a better choice for staining.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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