Anti-FLIP_L C-Terminal antibody produced in rabbit

In human Viral FLICE-inhibitory proteins (v-FLIPs) is identified as c-FLIP. It is composed of two death effector domains which have structural resemblance with the N-terminal half of caspase-8 and a caspase-like domain. It exist as multiple splice variants: FLIP α, β, γ, δ. Along with splice variants, it has two endogenous forms of the protein c-FLIP_long and c-FLIP_short.

The antibody does not react with short form, FLIP_S.

synthetic peptide corresponding to amino acids 449-465 of the C-terminal region of mouse FLIP_L.

Anti-FLIP_L C-Terminal antibody is suitable for western blot at 1-2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.

C-FLIP plays an important role in apoptosis signaling pathways. It acts as proapoptotic molecule or as an anti-apoptotic molecule. It has been reported that c-FLIP can interact with both FADD and caspase-8. It prevents caspase-8 recruitment and processing through DED-DED (death effector domain) interaction followed by CD95-induced apoptosis.

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

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