F8932
氢溴化他汀
≥98% (HPLC), powder
别名:
25B11 氢溴酸盐, 4- [4-(4-甲基苯基)-2-噻唑基]-2-丙基吡啶氢溴酸盐, 脂肪抑制素Fatostatin A氢溴酸盐；2-(2-丙基吡啶-4-基)-4-对甲苯噻唑氢溴酸盐
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关于此项目
经验公式（希尔记法）:
C18H18N2S·HBr
化学文摘社编号:
分子量:
375.33
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
产品名称
氢溴化他汀, ≥98% (HPLC), powder
SMILES string
[s]1c(nc(c1)c3ccc(cc3)C)c2cc(ncc2)CCC.Br
InChI
1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H
InChI key
RJCFNQZVFUMORB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light yellow to yellow
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Application
Fatostatin氢溴酸已被用于：
- 研究其抗癌活性以及对有丝分裂微管纺锤体的影响
- 研究其对气孔发育的影响
- 防止SREBP切割活化蛋白介导的固醇调控元件集合蛋白（SREBP）护送
Biochem/physiol Actions
Fatostatin氢溴酸是一种SREBP抑制剂。
Fatostatin氢溴酸是一种SREBP抑制剂。Fatostatin氢溴酸可通过抑制SREBP（固醇调节元素结合蛋白）来抑制小鼠脂肪的产生并降低葡萄糖水平。
General description
Fatostatin是一种非固醇二芳基噻唑衍生物。它可防止胰岛素诱导的脂肪生成，并降低脂肪酸、甘油三酯和低密度脂蛋白的含量。Fatostatin具有抗肿瘤和抗有丝分裂特性。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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: Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to investigate the therapeutic
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