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F8929

Sigma-Aldrich

氟康唑

≥98% (HPLC), powder, fungal cytochrome P-450 sterol C-14 α-demethyllation inhibitor

别名:

2-(2,4-二氟苯基)-1,3-双(1H-1,2,4-三唑-1-基)丙-2-醇

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About This Item

经验公式（希尔记法）:
C13H12F2N6O
CAS号:
86386-73-4
分子量:
306.27
MDL编号:
MFCD00274549
UNSPSC代码:
12352200
PubChem化学物质编号:
24724485
NACRES:
NA.77

产品名称

氟康唑, ≥98% (HPLC), powder

质量水平

100

方案

≥98% (HPLC)

表单

powder

溶解性

DMSO: 5 mg/mL

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

储存温度

room temp

SMILES字符串

FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1

InChI

1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2

InChI key

RFHAOTPXVQNOHP-UHFFFAOYSA-N

基因信息

human ... CYP1A2(1544)

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一般描述

氟康唑用于治疗中性细胞减少症成人患者的侵袭性假丝酵母菌病(IC)。

应用

氟康唑已用于评估最低抑菌浓度(MIC)-真菌检测。它还被用作植物抗真菌检测的阳性对照。

生化/生理作用

氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。

特点和优势

该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
0000409287
0000325354
0000328864
0000320225
0000299223

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Screening of selected medicinal plants for their antifungal properties
Aboh MI, et al.
African Journal of Clinical and Experimental Microbiolog, 20(1), 54-59 (2019)
Maiken Cavling Arendrup et al.
Antimicrobial agents and chemotherapy, 53(4), 1628-1629 (2009-02-04)
The fluconazole MIC distributions for Candida glabrata from testing 34 different clinical isolates and performing 51 tests on a single isolate mirrored each other. Since what is perceived as biological variation in isolates without resistance mechanisms is mainly methodological variation
Current antifungal drugs and immunotherapeutic approaches as promising strategies to treatment of fungal diseases
Nami S, et al.
Biomedicine and Pharmacotherapy, 110, 857-868 (2019)
Synthesis, structures and antimicrobial activity of novel NHC-and Ph3P-Ag (I)-Benzoate derivatives
O Beirne C, et al.
Inorgorganica Chimica Acta, 486, 294-303 (2019)
H M H N Bandara et al.
Scientific reports, 10(1), 7769-7769 (2020-05-10)
Microorganisms employ quorum sensing (QS) mechanisms to communicate with each other within microbial ecosystems. Emerging evidence suggests that intraspecies and interspecies QS plays an important role in antimicrobial resistance in microbial communities. However, the relationship between interkingdom QS and antimicrobial
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