product name
氟康唑, ≥98% (HPLC), powder
质量水平
检测方案
≥98% (HPLC)
形式
powder
溶解性
DMSO: 5 mg/mL
抗生素抗菌谱
fungi
作用机制
enzyme | inhibits
储存温度
room temp
SMILES字符串
FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
InChI
1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChI key
RFHAOTPXVQNOHP-UHFFFAOYSA-N
基因信息
human ... CYP1A2(1544)
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一般描述
氟康唑用于治疗中性细胞减少症成人患者的侵袭性假丝酵母菌病(IC)。
应用
氟康唑已用于评估最低抑菌浓度(MIC)-真菌检测。它还被用作植物抗真菌检测的阳性对照。
生化/生理作用
氟康唑是一种抗真菌剂。是真菌细胞色素P-450甾醇C-14α-去甲基化的高选择性抑制剂。氟康唑是一种有效的CYP2C9抑制剂。氟康唑可干扰真菌麦角甾醇合成并下调金属硫蛋白基因。
特点和优势
该化合物是ADME Tox研究的特色产品。点击此处 了解更多ADME Tox的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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The fluconazole MIC distributions for Candida glabrata from testing 34 different clinical isolates and performing 51 tests on a single isolate mirrored each other. Since what is perceived as biological variation in isolates without resistance mechanisms is mainly methodological variation
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