F8890
叶酸
BioReagent, suitable for plant cell culture, ≥97%
别名:
N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸, PteGlu, 维生素 M
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经验公式（希尔记法）:
C19H19N7O6
化学文摘社编号:
分子量:
441.40
UNSPSC Code:
12352200
PubChem Substance ID:
eCl@ss:
34058014
EC Number:
200-419-0
Beilstein/REAXYS Number:
100781
MDL number:
InChI key
OVBPIULPVIDEAO-LBPRGKRZSA-N
InChI
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
SMILES string
NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
product line
BioReagent
assay
≥97%
technique(s)
cell culture | plant: suitable
application(s)
agriculture
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General description
Folic acid is a vitamin that is reduced to dihydrofolate in vivo. Dihydrofolate is further reduced tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Thommey P Thomas et al.
Journal of medicinal chemistry, 48(11), 3729-3735 (2005-05-27)
The cellular uptake and cytotoxicity of an engineered multifunctional dendritic nanodevice containing folic acid (FA) as the targeting molecule, methotrexate (MTX) as the chemotherapeutic drug, and fluorescein (FI) as the detecting agent were studied in vitro. FI and FA were
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age
R Wendel Naumann et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4400-4406 (2013-10-16)
Vintafolide (EC145) is a folic acid-desacetylvinblastine conjugate that binds to the folate receptor (FR), which is expressed on the majority of epithelial ovarian cancers. This randomized phase II trial evaluated vintafolide combined with pegylated liposomal doxorubicin (PLD) compared with PLD
Roy Lardenoije et al.
Progress in neurobiology, 131, 21-64 (2015-06-15)
Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as
Séverine Ledoux et al.
Annals of surgery, 259(6), 1104-1110 (2014-05-14)
To study long-term nutritional deficits based on adherence to a standardized nutritional care after gastric bypass (GBP). Long-term prospective data on nutritional complications after GBP are missing. It is not known whether severe deficiencies are prevented by standard multivitamin supplementation
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