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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white to light brown
溶解性
DMSO: ≥40 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
InChI
1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
InChI key
XVUOIWIIQVGWAJ-UHFFFAOYSA-N
应用
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
生化/生理作用
FM19G11 is an inhibitor of Hypoxia Inducible Factor α (HIFα), reported to affect self-renewal and differentiation of stem cells.
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Eisuke Ueshima et al.
Liver cancer, 9(1), 63-72 (2020-02-20)
The underlying mechanism involved in the recurrence of hepatoma after hepatic arterial embolization (HAE) is not adequately examined. An immunosuppressive cytokine, transforming growth factor β1 (TGF-β1), can lead to tumor progression and is affected by hypoxia in various cancers. The
Chao-Guo You et al.
Cancer medicine (2018-05-16)
FM19G11 is a small molecular agent that inhibits hypoxia-inducible factor-1-alpha (HIF-1α) and other signaling pathways. In this study, we characterized the modulating effects of FM19G11 on O6 -methylguanine DNA-methyltransferase (MGMT), the main regulator of temozolomide (TMZ) resistance in glioblastomas. This
UV-protection timer controls linkage between stress and pigmentation skin protection systems
Malcov B, et al.
Molecular Cell, 72(3), 444-456 (2018)
Stefania Marcuzzo et al.
Cells, 8(3) (2019-03-27)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. In ALS mice, neurodegeneration is associated with the proliferative restorative attempts of ependymal stem progenitor cells (epSPCs) that normally lie in a quiescent in the spinal cord. Thus
Sung Ji Choi et al.
PloS one, 8(3), e58662-e58662 (2013-03-23)
Although both glucose deprivation and hypoxia have been reported to promote cascades of biological alterations that lead to induction of inflammatory mediators, we hypothesized that glucose deprivation and hypoxia might show neutral, synergistic or antagonistic effects to each other on
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