product name
FK866 盐酸盐 水合物, ≥98% (HPLC)
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
InChI
1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChI key
KPBNHDGDUADAGP-VAWYXSNFSA-N
一般描述
FK866用于治疗炎症性疾病和癌症。
应用
FK866盐酸盐已用于:
- 研究其对轴突内NAD+ 水平的影响
- 诱导NAD +耗竭
- 降低缺血性脑组织中肿瘤坏死因子-α (TNF-α)、烟酰胺磷酸核糖转移酶（NAMPT）和白介素6（IL-6）的水平
生化/生理作用
FK866是一种NAD生物合成的有效抑制剂，也是NAMPT（烟酰胺磷酸核糖基转移酶，内脂素，PBEF）的特异性抑制剂。NAMPT可作为细胞内和细胞外NAD生物合成酶起作用，其对于通过去乙酰化酶和其他消耗NAD的调节剂对代谢和应激抗性进行调节非常重要。NAMPT还可作为一种细胞因子（不依赖于其酶活性）在调节免疫反应中发挥重要作用。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes
Oyarzun AP, et al.
Biochemical Pharmacology, 98(1), 92-101 (2015)
Zhongju Tan et al.
Annals of clinical and translational neurology, 7(5), 742-756 (2020-04-18)
FK866 is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which exhibits neuroprotective effects in ischemic brain injury. However, in traumatic brain injury (TBI), the role and mechanism of FK866 remain unclear. The present research was aimed to investigate whether FK866 could
Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration
Chen CX, et al.
Neuroscience, 356, 193-206 (2017)
Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration
Shacham-Silverberg V, et al.
Cell Death & Disease, 9(11), 1116-1116 (2018)
Natasja Franceschini et al.
International journal of molecular sciences, 22(12) (2021-07-03)
For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabolism, which justifies targeting
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