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F8423

氟脲嘧啶

Name: 氟脲嘧啶
Brand: SIGMA

meets USP testing specifications

别名:

5-氟脲嘧啶, 2,4-二羟基-5-氟嘧啶, 5-FU, 5-氟-2,4(1H,3H)-嘧啶二酮

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关于此项目

经验公式（希尔记法）:

C₄H₃FN₂O₂

化学文摘社编号:

51-21-8

分子量:

130.08

UNSPSC Code:

12352207

NACRES:

NA.71

PubChem Substance ID:

24894963

EC Number:

200-085-6

Beilstein/REAXYS Number:

127172

MDL number:

MFCD00006018

Quality level:

200

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Quality Level

200

agency

USP/NF, meets USP testing specifications

mp

282-286 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

Gene Information

human ... TYMS(7298)

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

历史批次信息供参考:

分析证书(COA)

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In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives.

Julia K J Ahlskog et al.

Bioorganic & medicinal chemistry letters, 19(16), 4851-4856 (2009-07-21)

We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of

Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.

Zhiyang Chen et al.

Nature communications, 6, 6808-6808 (2015-04-17)

Wild-type p53-induced phosphatase 1 (Wip1) negatively regulates several tumour suppressor and DNA damage response pathways. However, the impact of Wip1 on haematopoietic stem cell (HSC) homeostasis and aging remains unknown. Here we show that Wip1 is highly expressed in HSCs

3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: a novel cluster of potent tumor-selective cytotoxins.

Umashankar Das et al.

Journal of medicinal chemistry, 54(9), 3445-3449 (2011-04-01)

Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a-e) display potent cytotoxicity and a preferential lethality toward various neoplasms compared to some normal cells. The corresponding sulfonic acid analogues 5a-e and an isostere 4 demonstrated substantially lower activity. The leads 3d and 3e possess very high

Design, synthesis and cytotoxic properties of novel 1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones and related compounds.

Umashankar Das et al.

European journal of medicinal chemistry, 42(1), 71-80 (2006-09-26)

The 3,5-bis(arylidene)-4-piperidones 1 contain the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore which is considered to interact at a complementary binding site in susceptible neoplasms. The hypothesis was formulated that the presence of an acyl group attached to the piperidyl nitrogen atom in series 1

Intrathoracic anastomotic leakage after gastroesophageal cancer resection is associated with increased risk of recurrence.

Steen C Kofoed et al.

The Journal of thoracic and cardiovascular surgery, 150(1), 42-48 (2015-05-20)

Intrathoracic anastomotic leakage after intended curative resection for cancer in the esophagus or gastroesophageal junction has a negative impact on long-term survival. The aim of this study was to investigate whether an anastomotic leakage was associated with an increased recurrence

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全球贸易项目编号

货号	GTIN
F8423-10G	04061834402480
F8423-5G	04061833620601

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