推荐产品
质量水平
方案
≥98% (TLC)
创始人
Johnson & Johnson
储存温度
2-8°C
SMILES字符串
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
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一般描述
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
应用
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
生化/生理作用
阻断 T 型 Ca2+/Na+ 通道;抑制嗜铬细胞中由 K+ 诱导的儿茶酚胺释放。
特点和优势
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种:
Effects of flunarizine on induced calcium transients as measured in fura-2-loaded neurons of the rat dorsal root ganglion
Naunyn-Schmiedeberg'S Archives of Pharmacology, 348(3), 269-274 (1993)
The effect of flunarizine on penicillin model epilepsy in rats
Journal of Experimental and Clinical Medicine, 16(4) (1999)
Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy
Epilepsia, 25(2), 217-222 (1984)
Flunarizine
Drugs, 27(1), 6-44 (1984)
Behavioural brain research, 228(1), 144-150 (2011-12-20)
The motivational component of drug withdrawal may contribute to drug seeking and relapse through the negative reinforcement-related process; thus, it is important to understand the mechanisms that mediate affective withdrawal behaviors. The present study was undertaken to examine the calcium-dependent
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