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Merck
CN

F8257

Sigma-Aldrich

氟桂嗪 二盐酸盐

≥98% (TLC)

别名:

1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐

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About This Item

经验公式(希尔记法):
C26H26F2N2 · 2HCl
CAS号:
分子量:
477.42
Beilstein:
4284243
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (TLC)

创始人

Johnson & Johnson

储存温度

2-8°C

SMILES字符串

Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4

InChI

1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

InChI key

RXKMOPXNWTYEHI-RDRKJGRWSA-N

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一般描述

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

应用

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

生化/生理作用

阻断 T 型 Ca2+/Na+ 通道;抑制嗜铬细胞中由 K+ 诱导的儿茶酚胺释放。

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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Effects of flunarizine on induced calcium transients as measured in fura-2-loaded neurons of the rat dorsal root ganglion
Leybaert L, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 348(3), 269-274 (1993)
The effect of flunarizine on penicillin model epilepsy in rats
BAGIRICI F, et al.
Journal of Experimental and Clinical Medicine, 16(4) (1999)
Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy
Overweg J, et al.
Epilepsia, 25(2), 217-222 (1984)
Flunarizine
Holmes B, et al.
Drugs, 27(1), 6-44 (1984)
Barbara Budzynska et al.
Behavioural brain research, 228(1), 144-150 (2011-12-20)
The motivational component of drug withdrawal may contribute to drug seeking and relapse through the negative reinforcement-related process; thus, it is important to understand the mechanisms that mediate affective withdrawal behaviors. The present study was undertaken to examine the calcium-dependent

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