产品名称
抗-c-Fos 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 50-60 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using human colorectal carcinoma tissue
western blot: 1:1,000 using nuclear extract of a phorbol ester-treated human A431 cells or nuclear extract of human A431 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FOS(2353)
Application
兔多克隆抗c-Fos抗体通过免疫印迹（作为50-62 kDa处的单个或多个条带）和免疫组织化学识别c-Fos。通过免疫印迹，该抗体还可以检测到约40 kDa的条带，该条带代表c-Fos降解产物。c-Fos免疫肽（人c-Fos，C末端添加赖氨酸的3-16个氨基酸）可以特异性抑制c-Fos的免疫印迹染色。
兔抗c-Fos抗体可用于免疫测定以确定脊髓切片中的c-fos免疫反应性。 它还用于免疫组织化学。
它可用作探针以确定c-Fos在多种细胞过程（包括细胞增殖和分化）中的存在和作用，以及对细胞损伤或应激的反应。
兔抗c-Fos抗体可用于免疫测定以确定脊髓切片中的c-fos免疫反应性。 它还用于免疫组织化学。
它可用作探针以确定c-Fos在多种细胞过程（包括细胞增殖和分化）中的存在和作用，以及对细胞损伤或应激的反应。
Biochem/physiol Actions
c-Fos（AP-1转录因子亚基）在细胞增殖和分化中起重要作用。此外，它可参与细胞对应激、细胞损伤和死亡的反应，并且在正常骨和造血细胞发育以及肿瘤发生中具有重要作用。在受到各种细胞外刺激（包括应激、促有丝分裂生长因子、细胞因子、神经递质和药理学试剂）的刺激后，几乎每种细胞类型都能快速和瞬时诱导c-Fos。 在一些人类癌症（包括结肠癌和胰腺癌）中c-Fos的表达增加。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
c-Fos属于转录因子家族，包括FosB、Fra1和Fra2。fos癌基因已经被分离为FBJ鼠骨肉瘤病毒携带的逆转录病毒转化基因（retroviral transforming gene，v-fos）。 c-Fos经过了翻译后修饰，研究人员也描述了其它形式，包括57 Da、60 kDa和62 kDa蛋白质。c-Fos在发育中的骨组织和牙齿、造血细胞、生殖细胞和中枢神经系统中表达稳定。c-Fos在人类足月胎膜中有高水平的表达。
Immunogen
对应于人c-Fos原癌基因（p55）的N-末端区域（氨基酸3-16）的合成肽。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
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