产品名称
Folate Receptor 2 人, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
biological source
human
recombinant
expressed in CHO cells
assay
≥95% (SDS-PAGE)
form
lyophilized
impurities
≤1.0 EU/μg endotoxin
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Quality Level
Gene Information
human ... FOLR2(2350)
Application
叶酸受体 2 已用于甲氨蝶呤 (MTX) 治疗类风湿性关节炎 (RA) 的研究。此类研究关注通过 RA 滑膜巨噬细胞中的叶酸受体 2 输送MTX。
Biochem/physiol Actions
叶酸受体 2 是一种 38 kDa 的蛋白质，对叶酸具有高度亲和力，介导 5-甲基四氢叶酸到细胞内部。
Physical form
用PBS 冻干
Preparation Note
在PBS 中以100 μg/mL重建
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)
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