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生物来源
human
质量水平
重组
expressed in CHO cells
方案
≥95% (SDS-PAGE)
表单
lyophilized
杂质
≤1.0 EU/μg endotoxin
UniProt登记号
应用
cell analysis
储存温度
−20°C
基因信息
human ... FOLR2(2350)
应用
叶酸受体 2 已用于甲氨蝶呤 (MTX) 治疗类风湿性关节炎 (RA) 的研究。此类研究关注通过 RA 滑膜巨噬细胞中的叶酸受体 2 输送MTX。
生化/生理作用
叶酸受体 2 是一种 38 kDa 的蛋白质，对叶酸具有高度亲和力，介导 5-甲基四氢叶酸到细胞内部。
外形
用PBS 冻干
重悬
在PBS 中以100 μg/mL重建
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)
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