生物来源
mouse
质量水平
偶联物
FITC conjugate
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
hVIN-1, monoclonal
形式
buffered aqueous solution
分子量
antigen 116 kDa
种属反应性
frog, chicken, mouse, canine, human, bovine, rat, turkey
储存条件
protect from light
技术
direct immunofluorescence: 1:50 using methanol/acetone fixed cultured bovine MDBK cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... VCL(7414)
mouse ... Vcl(22330)
rat ... Vcl(305679)
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特异性
特异性标记细胞间和细胞-基质连接处的黏着斑蛋白。与人黏着斑蛋白反应强烈。与平滑肌黏着斑蛋白剪切变体metavinculin具有交叉反应性。
免疫原
来自子宫的纯化人黏着斑蛋白。
应用
抗黏着斑蛋白-FITC单克隆抗体适用于成纤维细胞的免疫荧光染色，以研究纳米纤维空间组织对细胞行为的影响。它还适用于使用甲醇/丙酮固定培养的牛 MDBK 细胞（1:50 稀释）进行直接免疫荧光。
生化/生理作用
纽蛋白是一种细胞骨架蛋白，分子量约为 116 kDa。纽蛋白与粘附膜区域密切相关，例如黏着斑、足体或黏着小带类细胞间连接。它充当整合素和肌动蛋白细胞骨架相互作用的介质。它在整合素、细胞表面 ECM 分子受体和 F-肌动蛋白细胞骨架之间架起一座桥梁。它与踝蛋白和α-肌动蛋白相关，后者直接与整合素连接。在黏着斑装配过程中，黏着斑蛋白还与α-连环蛋白和血管扩张剂刺激磷蛋白（VASP）结合。
外形
溶于0.01M磷酸盐缓冲盐水，pH 7.4，含有1%牛血清白蛋白以及15 mM叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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