检测方案
≥97.0% (HPLC)
形式
powder
颜色
white to off-white
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
SMILES字符串
CC1CCc2cc(F)cc3C(=O)C(=CN1c23)C(O)=O
InChI
1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)
InChI key
DPSPPJIUMHPXMA-UHFFFAOYSA-N
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一般描述
化学结构：氟喹诺酮
生化/生理作用
泛黄素抑制拓扑异构酶，这是细菌 DNA 转录和复制所必需的。拓扑异构酶的抑制导致细菌染色体的链断裂、超螺旋和重新封闭。因此，DNA 复制和转录被抑制。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Etienne Giraud et al.
Journal of medical microbiology, 53(Pt 9), 895-901 (2004-08-18)
The mechanisms of resistance to quinolone and epidemiological relationships among A. salmonicida strains isolated from diseased fish in French marine farms from 1998 to 2000 were investigated. The quinolone resistance-determining regions of the gyrA and parC genes of 12 clinical
Yoko Kashida et al.
Toxicological sciences : an official journal of the Society of Toxicology, 69(2), 317-321 (2002-10-16)
In order to elucidate the tumor-initiating potential of flumequine (FL) in the liver, male C3H mice were given dietary administration of 4000 ppm FL throughout the study or for 2 weeks at the initiation stage, and then received 2 intraperitoneal
I Guillemin et al.
Microbiology (Reading, England), 145 ( Pt 9), 2527-2532 (1999-10-12)
The DNA gyrases from Mycobacterium avium, Mycobacterium smegmatis and Mycobacterium fortuitum bv. peregrinum, which are species naturally resistant, moderately susceptible and susceptible to fluoroquinolones, respectively, were purified by affinity chromatography on novobiocin-Sepharose columns. The DNA gyrase inhibiting activities (IC50 values)
E Giraud et al.
Antimicrobial agents and chemotherapy, 43(9), 2131-2137 (1999-09-03)
The occurrence of mutations in the genes coding for gyrase (gyrA and gyrB) and topoisomerase IV (parE and parC) of Salmonella typhimurium experimental mutants selected in vitro and in vivo and of 138 nalidixic acid-resistant Salmonella field isolates was investigated.
C Ferraresi et al.
Poultry science, 92(12), 3158-3165 (2013-11-16)
Flumequine (FLU) is used in the treatment of systemic bacterial infections in poultry, including colibacillosis, which is a common disease in turkeys. The pharmacokinetic (PK) behavior of FLU administered to 32 healthy turkeys as an oral bolus via gavage or
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