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关于此项目
经验公式(希尔记法):
C8H15N7O2S3
化学文摘社编号:
分子量:
337.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
法莫替丁,
SMILES string
N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1
InChI key
XUFQPHANEAPEMJ-UHFFFAOYSA-N
InChI
1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
originator
Johnson & Johnson
Quality Level
Gene Information
human ... HRH2(3274)
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相关类别
Application
法莫替丁已用于测试其对HEK293膜中转染的人ether-a-go-go相关基因(hERG)结合的效应。它也被用于基于聚己内酯的药物递送研究。
Biochem/physiol Actions
法莫替丁对毒蕈碱和烟碱样受体无效。它竞争性地抑制胃酸的分泌,并引发粘膜损伤保护。
H2组胺受体拮抗剂;抗溃疡剂。
Features and Benefits
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
Taha AS, et al.
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Famotidine: an update review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied disease
Healther DL, et al.
Drugs, 38(3), 551-590 (2015)
Makoto Anraku et al.
International journal of pharmaceutics, 487(1-2), 142-147 (2015-04-18)
An intermolecular complex formed from a 1:1 weight ratio of chitosan (CS, molecular weight 30 kDa) and sulfobutyl ether β-cyclodextrin (SBE-β-CyD, degree of substitution 7) was less soluble than either of the original components. The release of famotidine from tablets
Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design
Schlesinger E, et al.
Materials Science and Engineering, C, 57, 232-239 (2015)
The [3H] dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+] o
Diaz GJ, et al.
Journal of Pharmacological and Toxicological Methods, 50(3), 187-199 (2004)
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