F6771
Fumagillin
from Aspergillus sp. (Aspergillus fumigatus), ≥90% (HPLC), powder, MetAP2 inhibitor
别名:
Fugillin
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关于此项目
经验公式（希尔记法）:
C26H34O7
化学文摘社编号:
分子量:
458.54
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
245-433-8
MDL number:
产品名称
Fumagillin from Aspergillus fumigatus, ≥90%, powder
SMILES string
COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
InChI
1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
InChI key
NGGMYCMLYOUNGM-HCNIIHBUSA-N
biological source
Aspergillus sp. (Aspergillus fumigatus)
assay
≥90%
form
powder
color
white
mp
197-198 °C
solubility
ethanol: 1 mg/mL
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Fumagillin is known to be effective against microsporidian fungal infections.
Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.
Application
Fumagillin from Aspergillus fumigatus has been used:
- in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
- to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
- as a positive control in in vitro and ex vivo studies
General description
Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
The effect of dicyclohexylamine and fumagillin on Nosema ceranae-infected honey bee (Apis mellifera) mortality in cage trial assays
Van den Heever JP, et al.
Apidologie, 47(5), 663-670 (2016)
Fumagillin: an overview of recent scientific advances and their significance for apiculture
van den Heever JP, et al.
Journal of Agricultural and Food Chemistry, 62(13), 2728-2737 (2014)
A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay
Miller WJ, et al.
Journal of Translational Medicine, 2(1), 4-4 (2004)
A Audemard et al.
Transplant infectious disease : an official journal of the Transplantation Society, 14(6), E147-E149 (2012-10-03)
Microsporidiosis is an opportunistic infection in organ transplant recipients and patients with other cellular immunodeficiency. Fumagillin is an effective treatment against Enterocytozoon bieneusi, one of the two main species causing the microsporidiosis involved in human diseases. We report the first
Maki Kanda et al.
Journal of AOAC International, 94(3), 878-885 (2011-07-30)
A new, rapid, and efficient method for determining the fumagillin residues in honey was developed. The samples extracted were analyzed using LC/MS/MS. Chromatographic separation of fumagillin was performed in gradient mode on a C8 column (100 x 2.0 mm, 5
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