所有图片(1)
About This Item
经验公式（希尔记法）:
C13H10Cl2N2O4S
CAS号:
分子量:
361.20
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
溶解性
DMSO: 20 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1cc(ccc1NS(=O)(=O)c2cc(Cl)ccc2Cl)[N+]([O-])=O
InChI
1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChI key
AXNUEXXEQGQWPA-UHFFFAOYSA-N
生化/生理作用
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
FH535 is a reversible dual inhibitor of Wnt/β-catenin and PPARγ and PPARδ signaling antagonist; β-catenin/Tcf inhibitor.
FH535 is a reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling antagonist. FH535 is unique in its ability to inhibit the Wnt/β-catenin pathway. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Wei Xie et al.
The international journal of biochemistry & cell biology, 103, 45-55 (2018-08-11)
Triple negative breast cancer (TNBC) is one of the most difficult malignancy to treat due to a lack of targeted therapy. Studies have demonstrated that the activation of Wnt/β-catenin signaling was preferentially found in TNBC. Frizzled-7 (Fzd7), one of the
FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases
Gustafson C T, et al.
Frontiers in Pharmacology, 8, 285-285 (2017)
FH535 Inhibits Proliferation and Motility of Colon Cancer Cells by Targeting Wnt beta-catenin Signaling Pathway
Chen Y, et al.
Journal of Cancer, 8(16), 3142-3142 (2017)
Yong-Yu Liu et al.
Molecular cancer, 9, 145-145 (2010-06-15)
Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other gene alterations including enhanced glucosylceramide synthase (GCS). MDR1 encodes for P-glycoprotein
P-J Royer et al.
Respiratory research, 18(1), 208-208 (2017-12-15)
Airway epithelial cells (AEC) act as the first line of defence in case of lung infections. They constitute a physical barrier against pathogens and they participate in the initiation of the immune response. Yet, the modalities of pathogen recognition by
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