F5006
2-氟-2-脱氧-D-葡萄糖
glycosylation inhibitor, glucose analog
别名:
2-脱氧-2-氟-D–葡萄糖, FDG, 2-脱氧-2-氟-D-葡萄糖
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关于此项目
经验公式（希尔记法）:
C6H11FO5
化学文摘社编号:
分子量:
182.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
2-氟-2-脱氧-D-葡萄糖, glycosylation inhibitor, glucose analog
InChI key
ZCXUVYAZINUVJD-UHFFFAOYSA-N
SMILES string
OCC1OC(O)C(F)C(O)C1O
InChI
1S/C6H11FO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1H2
Quality Level
assay
≥98.00% (TLC)
form
powder
mol wt
182.15 g/mol
concentration
≤100% (2-Fluoro-2-deoxy-D-glucose)
color
, white to white with yellow cast
mp
174-176 °C
solubility
water: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
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Application
2-氟-2-脱氧-D-葡萄糖被用作快速肿瘤检测的示踪剂。它被用作葡萄糖模拟物，以研究辐射和烧伤小鼠的葡萄糖摄取。肿瘤治疗研究使用FDG联合PET（正电子发射地形图）
Biochem/physiol Actions
抑制细胞糖基化的葡萄糖类似物。
General description
2-氟-2-脱氧-D-葡萄糖无毒，是葡萄糖的结构类似物，显著抑制了糖基化。作为葡萄糖类似物，2-氟-2-脱氧-D-葡萄糖在大脑和心脏细胞中可被迅速摄取。
2-氟-2-脱氧-D-葡萄糖可以被细胞吸收，但不进行代谢性糖酵解。
2-氟-2-脱氧-D-葡萄糖可以被细胞吸收，但不进行代谢性糖酵解。
hcodes
signalword
Warning
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Edward A Carter et al.
Journal of burn care & research : official publication of the American Burn Association, 33(6), 723-730 (2012-11-13)
Radiation exposure and burn injury have both been shown to alter glucose utilization in vivo. The present study was designed to study the effect of burn injury combined with radiation exposure on glucose metabolism in mice using [¹⁸F] 2-fluoro-2-deoxy-D-glucose (¹⁸FDG).
Johan Stender et al.
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Bedside clinical examinations can have high rates of misdiagnosis of unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The diagnostic and prognostic usefulness of neuroimaging-based approaches has not been established in a clinical setting. We did a validation study
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