推荐产品
产品名称
呋塞米,
生物来源
synthetic (organic)
质量水平
方案
≥98% (HPLC)
表单
powder
mp
220 °C (dec.) (lit.)
溶解性
acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
创始人
Sanofi Aventis
储存温度
room temp
SMILES字符串
NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
InChI
1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
InChI key
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
基因信息
human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)
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一般描述
Furosemide is a an ototoxic high-ceiling diuretic.
应用
Furosemide has been used:
- to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
- to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
- as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)
生化/生理作用
"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.
抑制肾脏中离子的协同运输。
特点和优势
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection
Fernandes V T and Lin V YW
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale, 43(1), 12-12 (2014)
Furosemide
Saunders Handbook of Veterinary Drugs - E-Book (2016)
Causes of acquired hearing loss
Eggermont J J
Hearing Loss: Causes, Prevention, and Treatment (2017)
Comparison of arterial pressure and plasma AngII responses to three methods of subcutaneous AngII administration
Kuroki M T, et al.
American Journal of Physiology. Heart and Circulatory Physiology (2014)
Topiramate is more effective than acetazolamide at lowering intracranial pressure
Scotton W J, et al.
Cephalalgia, 0333102418776455-0333102418776455 (2018)
商品
Discover Bioactive Small Molecules for ADME/Tox
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