所有图片(1)
About This Item
经验公式（希尔记法）:
C12H11NOS2
CAS号:
分子量:
249.35
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
yellow
溶解性
DMSO: >10 mg/mL
H2O: <2 mg/mL
储存温度
2-8°C
SMILES字符串
CCc1ccc(cc1)\C=C2\SC(=S)NC2=O
InChI
1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
InChI key
SVXDHPADAXBMFB-JXMROGBWSA-N
应用
10058-F4 已用于:
- 作为c-Myc抑制剂用于处理基质细胞
- 作为c-Myc抑制剂用于确定c-Myc抑制对心脏祖细胞（CPC）生长的影响
- 作为 c-Myc 抑制剂用于培养T细胞
- 处理C4-2细胞以考察MST1启动子荧光素酶报告基因构建体（reporter construct）的活性
生化/生理作用
10058-F4是一种c-Myc抑制剂，可诱导细胞周期组滞和细胞凋亡。10058-F4是一种细胞渗透性噻唑烷酮，它能够特异性地抑制c-Myc-Max相互作用并阻止c-Myc靶基因表达的反式激活。10058-F4在体外和体内均以c-Myc依赖性方式抑制肿瘤细胞生长（64 μM，使用c-Myc转染的Rat1a成纤维细胞）。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Bellio MA, et al.
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Bethany C Prudner et al.
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