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安全信息

F3418

Sigma-Aldrich

Monoclonal Anti-Cytokeratin, pan−FITC antibody produced in mouse

clone C-11, purified immunoglobulin, buffered aqueous solution

别名:

Monoclonal Anti-Pan Cytokeratin

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

200

偶联物

FITC conjugate

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

C-11, monoclonal

表单

buffered aqueous solution

种属反应性

bovine, mouse, frog, human, kangaroo rat, rat

储存条件

protect from light

技术

direct immunofluorescence: 1:50 using PtK2 cells
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50 using human placenta
western blot: suitable

同位素/亚型

IgG1

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

bovine ... Krt1(100301161)
human ... KRT1(3848) , KRT13(3858) , KRT13(3858) , KRT18(3875) , KRT18(3875) , KRT4(3851) , KRT4(3851) , KRT5(3852) , KRT5(3852) , KRT6A(3868) , KRT6A(3868) , KRT6B(3854) , KRT6B(3854) , KRT8(3856) , KRT8(3856)
mouse ... Krt1(16678) , Krt10(16661) , Krt10(16661) , Krt13(16663) , Krt13(16663) , Krt18(16668) , Krt18(16668) , Krt4(16682) , Krt4(16682) , Krt5(110308) , Krt5(110308) , Krt6a(16687) , Krt6a(16687) , Krt6b(16688) , Krt6b(16688) , Krt8(16691) , Krt8(16691)
rat ... Krt1(300250) , Krt1-18(706059) , Krt1-18(706059) , Krt10(450225) , Krt10(450225) , Krt2-5(369017) , Krt2-5(369017) , Krt2-8(25626) , Krt2-8(25626)

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相关类别

一般描述

Cytokeratins are the intermediate filaments of endocrine cells. These proteins belong to the intermediate filament (10 nm) superfamily of cytoskeletal proteins. Cytokeratins are the largest and most complex group of intermediate filaments. The family consists of at least 30 proteins with molecular weights ranging from 40kDa to 68kDa.

免疫原

keratin-enriched preparation from cultured human epidermoid carcinoma cell line A431.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Monoclonal Anti-Cytokeratin, pan−FITC antibody has been used in immunocytochemistry and has also been used to visualize lung epithelial cells.

生化/生理作用

Cytokeratins helps in subtyping several kinds of epithelial differentiation or for narrowing possible sites of origin for metastatic carcinomas. Cytokeratins may play an important role in transhepatic transport and canalicular secretion.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

含少量动物源组分生物产品
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分析证书(COA)

Lot/Batch Number
0000226332
0000226332
0000187125
0000166455
0000166455

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Potential biological role of transforming growth factor-beta in human congenital kidney malformations
Yang Su P, et al.
The American Journal of Pathology, 157(5), 1633-1647 (2000)
Autocrine GABA signaling distinctively regulates phenotypic activation of mouse pulmonary macrophages
Januzi L, et al.
Cellular Immunology, 332(2), 7-23 (2018)
Olivia Jerczynski et al.
PloS one, 11(10), e0163876-e0163876 (2016-10-04)
Dicer1 is an endoribonuclease involved in the biogenesis of functional molecules such as microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs). These small non-coding RNAs are important regulators of post-transcriptional gene expression and participate in the control of male fertility.
Kazuhito Sakamoto et al.
Molecular endocrinology (Baltimore, Md.), 21(8), 1877-1892 (2007-05-24)
Using a conditional knockout approach, we previously demonstrated that the Janus kinase 2 (Jak2) is crucial for prolactin (PRL) signaling and normal mammary gland development. PRL is suggested to synchronously activate multiple signaling cascades that emerge on the PRL receptor
C J Morrow et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 27(6), 1155-1160 (2016-03-26)
Over the past decade, numerous reports describe the generation and increasing utility of non-small-cell lung cancer (NSCLC) patient-derived xenografts (PDX) from tissue biopsies. While PDX have proven useful for genetic profiling and preclinical drug testing, the requirement of a tissue
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