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Merck
CN
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安全信息

F3254

Sigma-Aldrich

Fibrinopeptide A 人

≥96% (HPLC)

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About This Item

经验公式（希尔记法）:
C63H97N19O26
CAS号:
25422-31-5
分子量:
1536.56
MDL编号:
MFCD00076437
UNSPSC代码:
12352202
PubChem化学物质编号:
24894837
NACRES:
NA.77

生物来源

human

质量水平

200

方案

≥96% (HPLC)

表单

powder

技术

ELISA: suitable
mass spectrometry (MS): suitable

UniProt登记号

P02671

储存温度

−20°C

SMILES字符串

CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(O)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(C)N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(O)=O

InChI

1S/C63H97N19O26/c1-29(2)19-37(57(102)73-32(6)53(98)76-35(15-17-48(91)92)55(100)70-24-43(85)68-23-42(84)69-25-46(88)82-51(30(3)4)61(106)77-36(62(107)108)13-10-18-67-63(65)66)79-58(103)38(20-33-11-8-7-9-12-33)80-59(104)39(21-49(93)94)75-45(87)27-71-54(99)34(14-16-47(89)90)74-44(86)26-72-56(101)41(28-83)81-60(105)40(22-50(95)96)78-52(97)31(5)64/h7-9,11-12,29-32,34-41,51,83H,10,13-28,64H2,1-6H3,(H,68,85)(H,69,84)(H,70,100)(H,71,99)(H,72,101)(H,73,102)(H,74,86)(H,75,87)(H,76,98)(H,77,106)(H,78,97)(H,79,103)(H,80,104)(H,81,105)(H,82,88)(H,89,90)(H,91,92)(H,93,94)(H,95,96)(H,107,108)(H4,65,66,67)

InChI key

JWICNZAGYSIBAR-UHFFFAOYSA-N

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PFS20

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SpheriCal™ Neat Protein Low, suitable for MALDI-MS

PFS23

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SpheriCal™ Neat Peptide Medium, suitable for MALDI-MS

PFS21

SpheriCal™ Neat

SpheriCal™ Neat Peptide High, suitable for MALDI-MS

PFS22

SpheriCal™ Neat

product line

SpheriCal™

product line

SpheriCal™

product line

SpheriCal™

product line

SpheriCal™

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

form

solid

form

solid

form

solid

form

solid

shelf life

expiry date on the label

shelf life

expiry date on the label

shelf life

expiry date on the label

shelf life

expiry date on the label

mol wt

Mr 500-1600 Da (Na+-adduct)

mol wt

Mr 7500-15000 Da (Na & adduct)

mol wt

Mr 1600-3500 Da (Na & adduct)

mol wt

Mr 3500-7500 Da (Na+-adduct)

Amino Acid Sequence

Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg

一般描述

Fibrinopeptide A (FPA) is produced from the N-terminal Aα region of fibrinogen protein, on cleavage by thrombin. It is composed of 16 amino acids.[1]

应用

Fibrin polymerization is initiated by thrombin cleavage of fibrinopeptide A from fibrinogen α chains, exposing two E domain E(A) sites.

生化/生理作用

Fibrin polymerization is initiated by thrombin cleavage of fibrinopeptide A from fibrinogen α chains, exposing two E domain E(A) sites. The phenylalanine at α chain residue 8 is important for efficient thrombin-catalyzed proteolysis of fibrinogen. Substitution of tyrosine for phenylalanine blocks sequential fibrinopeptide release and, thus, blocks polymerization and clot formation.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000395659
    0000316864
    0000295503
    0000316864
    0000395659

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    Xi Chen et al.
    Environmental toxicology and pharmacology, 33(2), 191-196 (2012-01-10)
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine disruptors. To investigate peptide changes in the sera of rats chronically exposed to TCDD and to explore the association of these changes with liver morphology, TCDD was administrated to male rats at doses
    H L Nossel et al.
    The Journal of clinical investigation, 54(1), 43-53 (1974-07-01)
    Since thrombin cleaves fibrinopeptides A (FPA) and B from the NH(2)-terminal end of the fibrinogen molecule, measurement of fibrinopeptide levels in plasma may provide a direct index of thrombin action. Recently a radioimmunoassay for FPA has been developed, and in
    Laura A Da Costa et al.
    The Journal of nutritional biochemistry, 24(1), 396-400 (2012-12-04)
    Vitamin E is a lipophilic antioxidant that has been inversely associated with certain chronic diseases; however, the biological processes regulated by this vitamin have not been fully elucidated. The objective of the present study was to examine the association between
    Thromboprophylaxis in patients receiving chemotherapy.
    Claude Bachmeyer et al.
    The New England journal of medicine, 366(19), 1839-1839 (2012-05-11)
    J I Weitz
    Thrombosis and haemostasis, 75(4), 529-535 (1996-04-01)
    There is good evidence that thrombolytic therapy induces a procoagulant state that retards the lytic process and triggers reocclusion. Thus, both in experimental animal systems and in humans, potent inhibitors of platelets and antithrombin III-independent thrombin inhibitors have been shown
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