F2878
Ficoll® PM 70
Type 70
别名:
聚（蔗糖-共-表氯醇）
产品名称
Ficoll® PM 70, Type 70
type
Type 70
form
powder
mol wt
~70,000
color
white
solubility
H2O: soluble 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
Quality Level
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Application
Ficoll® PM 70已用于：
- 用作比较研究中的大分子，评估其在玻璃化溶液中的效果
- 用作卵母细胞玻璃化过程的玻璃化溶液补充剂
- 用作人肺成纤维细胞培养的低血清培养基成分，促进形成拥挤环境
Biochem/physiol Actions
Ficoll 常用作玻璃化溶液的大分子成分。由于其密集的分支，Ficolls也可用作理想的近球形分子拥挤剂。
在细胞体积信号转导和蛋白质重折叠研究中，FicollTM PM 70用作大分子拥挤剂。这一物质可用于组织工程和大分子构象研究，开发、评估和使用大分子拥挤 (MMC) 系统和配置。 Ficoll PM-70还可用于玻璃化研究。
General description
Ficoll® PM70是一种高分子量支化多糖聚合物，公认不含任何离子化基团。这种蔗糖聚合物由蔗糖与环氧氯丙烷共聚形成。
Legal Information
Ficoll is a registered trademark of Cytiva
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Pascal Salvetti et al.
Theriogenology, 74(5), 847-855 (2010-06-24)
The cryopreservation of oocytes is valuable for the preservation of women's fertility and might also be an interesting tool to preserve animal genetic biodiversity but it is not often used because of the very poor fertility recovered after thawing, especially
Emmanuel Dauty et al.
Journal of molecular recognition : JMR, 17(5), 441-447 (2004-09-14)
Aqueous environments in living cells are crowded, with up to >50 wt% small and macromolecule-size solutes. We investigated quantitatively one important consequence of molecular crowding--reduced diffusion of biologically important solutes. Fluorescence correlation spectroscopy (FCS) was used to measure the diffusion
Nobuhiko Tokuriki et al.
Protein science : a publication of the Protein Society, 13(1), 125-133 (2003-12-24)
Unfolded states of ribonuclease A were used to investigate the effects of macromolecular crowding on macromolecular compactness and protein folding. The extent of protein folding and compactness were measured by circular dichroism spectroscopy, fluorescence correlation spectroscopy, and NMR spectroscopy in
M B Burg
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 10(5-6), 251-256 (2000-12-23)
The non-ideal properties of solutions containing high concentrations of macromolecules can result in enormous increases in the activity of the individual macromolecules. There is considerable evidence that macromolecular crowding and confinement not only occur in cells, but that these are
M Al-Habori
The international journal of biochemistry & cell biology, 33(9), 844-864 (2001-07-20)
Macromolecular crowding has been proposed as a mechanism by means of which a cell can sense relatively small changes in volume or, more accurately, the concentration of intracellular solutes. According to the macromolecular theory, the kinetics and equilibria of enzymes
实验方案
Ficoll 400® is a non-ionic polymer with high hydrophilicity and water solubility, suitable for various biological applications.
Ficoll 400®是由蔗糖和环氧氯丙烷共聚而成的一种高度分支化的聚合物。Ficoll 400®是完全非离子性的。由于其含有丰富的羟基，Ficoll 400®具有很强的亲水性和水溶性。
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