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生物来源
bovine serum (fetal)
质量水平
形式
lyophilized powder
技术
cell culture | mammalian: suitable
杂质
≤0.3% free N-acetylneuraminic acid
溶解性
H2O: 1 mg/mL, colorless to faint yellow or tan
UniProt登记号
储存温度
2-8°C
基因信息
bovine ... FETUB(504615)
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一般描述
Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.
应用
Fetuin from fetal bovine serum has been used:
- to synthesize primary and secondary calciprotein particles (CPP)
- to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
- as a supplement in Ham′s F10 media for myoblast culture.
Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
生化/生理作用
Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.
制备说明
Prepared by ammonium sulfate fractionation of fetal calf serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
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