推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
A42, monoclonal
形式
buffered aqueous solution
分子量
antigen ~74 kDa
种属反应性
human
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 2-4 μg/mL using total cell extract of HEK 293T cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FXR2(9513)
一般描述
Monoclonal Anti-FXR2 (mouse IgG1 isotype) is derived from the hybridoma A42 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with human Fragile X mental retardation syndrome-related protein 2 (FXR2) recombinant protein. FXR2 gene is located on human chromosome 17 and its protein is localized mainly in the cytoplasm. FXR2 is expressed along with other proteins in the cytoplasm of neurons. It is characterized with two KH domains and one RGG box that together with fragile X mental retardation 1 (FMR1) bind to RNA. FXR2 is highly expressed in brain and testis.
特异性
Monoclonal Anti-FXR2 recognizes human, monkey, bovine, canine, rat, hamster, and mouse, FXR2, ~74 kDa, and does not crossreact with FMR or FXR1.
免疫原
human FXR2 recombinant protein.
应用
Anti-FXR2 antibody, Mouse monoclonal may be used in:
- immunoblotting
- immunoprecipitation
- immunocytochemistry
- immunohistochemistry
- co-immunoprecipitation
- immunofluorescence
- sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)
生化/生理作用
Fragile X mental retardation syndrome-related protein 2 (FXR2) is capable of forming heteromers with the others and can also form homomers. It has an independent function in tissues during embryonic development and adult life.
Fragile X mental retardation syndrome-related protein 2 (FXR2) knockout mice are hyperactive in the open-field test, impaired on the rotarod test, have reduced levels of prepulse inhibition, display less contextual conditioned fear, are impaired at locating the hidden platform in the Morris water task, and less sensitive to heat stimulus.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2–8 °C for up to one month. For prolonged storage, freeze in working aliquots. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion
eLife, 6, e26129-e26129 (2017)
Knockout mouse model for Fxr2: a model for mental retardation
Human Molecular Genetics, 11(5), 487-498 (2002)
Widespread RNA editing dysregulation in brains from autistic individuals
Nature Neuroscience, 22(1), 25-25 (2019)
The Journal of comparative neurology, 526(1), 96-108 (2017-09-09)
Local axonal protein synthesis plays a crucial role in the formation and function of neuronal circuits. Understanding the role of this mechanism in specific circuits requires identifying the protein composition and mRNA cargos of the ribonucleoprotein particles (RNPs) that form
Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway
Human Molecular Genetics, 27(3), 475-485 (2017)
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