生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 97 kDa
种属反应性
mouse
技术
western blot: suitable using mouse brain lysate
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
mouse ... Apbb1(11785)
特异性
The antibody does not detect endogenous levels of Fe65.
免疫原
synthetic peptide corresponding to amino acid residues 352-369 from mouse Fe65.
应用
Anti-Fe65 antibody produced in rabbit is suitable for western blotting using mouse brain lysate.
生化/生理作用
Amyloid β A4 precursor protein-binding family B member 1 is a protein encoded by the APBB1 gene in humans and is mapped on human metaphase chromosomes to band 11p15. Fe65 is a neuronal adaptor protein that is involved in brain development, Alzheimer disease amyloid precursor protein (APP) signaling and proteolytic processing of APP. It participates in various processes by recruiting various interacting partners to form functional complexes and acts as a novel regulator of neurite outgrowth. Fe65 significantly alters actin dynamics and mitochondrial function in neuronal cells.
外形
Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Hei Nga Maggie Cheung et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(1), 337-349 (2013-09-24)
FE65 is an adaptor protein that binds to the amyloid precursor protein (APP). As such, FE65 has been implicated in the pathogenesis of Alzheimer's disease. In addition, evidence suggests that FE65 is involved in brain development. It is generally believed
S L Bressler et al.
Human molecular genetics, 5(10), 1589-1598 (1996-10-01)
Using the yeast two hybrid system, a mouse embryo cDNA library was screened for proteins that interact with the C-terminus of the human beta-amyloid precursor protein (beta PP). A fusion protein was identified that interacts specifically with the cytoplasmic domain
Jens Radzimanowski et al.
The Journal of biological chemistry, 283(34), 23113-23120 (2008-06-14)
The neuronal adaptor protein Fe65 is involved in brain development, Alzheimer disease amyloid precursor protein (APP) signaling, and proteolytic processing of APP. It contains three protein-protein interaction domains, one WW domain, and a unique tandem array of phosphotyrosine-binding (PTB) domains.
Manus W Ward et al.
Journal of neurochemistry, 113(1), 275-284 (2010-04-21)
The amyloid precursor protein (APP) is critically involved in the pathogenesis of Alzheimer's disease, and is strongly up-regulated in response to traumatic, metabolic, or toxic insults to the nervous system. The processing of APP by gamma/epsilon-secretase activity results in the
Guo-Bo Chen et al.
Human genetics, 124(4), 393-398 (2008-09-09)
Although epidemiological studies reveal that cigarette smoking is inversely associated with Alzheimer's disease (AD) and Parkinson's disease (PD), the underlying mechanism remains largely unknown. Considering the facts that amyloid precursor protein-binding protein, family B, member 1 (APBB1) is mapped to
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