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About This Item
经验公式（希尔记法）:
C25H22ClNO3
CAS号:
分子量:
419.90
Beilstein:
2025982
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
一般描述
Fenvalerate an ester molecule, exists in four stereoisomers with two chiral centers.
应用
Fenvalerate has been used to study the effect of Fen exposure on reproductive functions.
生化/生理作用
Fenvalerate has good insecticidal potential and is less toxic to animals. It might cause endocrine disruption and reproductive dysfunction in humans. Metabolism of fenvalerate includes oxidation, ester cleavage and conjugation reaction. It is stable at pH 5 and 7, while it gets hydrolyzed at pH 9. In rat models it is found to hinder the action of mitochondrial enzymes.
Fenvalerate is a type II semi-synthetic pyrethrin, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B). This inhibitory action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell.
II 型拟除虫菊酯。强效钙调磷酸酶（蛋白磷酸酶 2B）抑制剂。
制备说明
Fenvalerate has been reported to be soluble in DMSO, ethanol, and acetone.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Paternal fenvalerate exposure influences reproductive functions in the offspring
Xia D, et al.
Reproductive Sciences, 20(11), 1308-1315 (2013)
Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil
Prasanthi K, et al.
Food And Chemical Toxicology, 43(2), 299-306 (2005)
Effects of fenvalerate exposure on semen quality among occupational workers
Lifeng T, et al.
Contraception, 73(1), 92-96 (2006)
Metabolic Pathways of Agrochemicals: Insecticides and fungicides, 659-659 (1998)
Terrence L Adelsbach et al.
Reviews of environmental contamination and toxicology, 176, 137-154 (2002-11-22)
Fenvalerate is listed under Class IV of the U.S. Food and Drug Administration (USFDA) Surveillance Index Classification, indicating a low hazard potential to humans from both exposure and toxicological standpoints; thus, minimal monitoring is required (Reed 1981; Eisler 1992). To
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