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Merck
CN

F134

S(+)-α-Fluoromethylhistidine hydrochloride

solid

别名:

MK-453, S(+)-α-FMH

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经验公式（希尔记法）:
C7H10FN3O2 · HCl
分子量:
223.63
UNSPSC Code:
12352200
MDL number:
MFCD01862670

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SMILES string

Cl.N[C@@](CF)(Cc1c[nH]cn1)C(O)=O

form

solid

color

off-white

solubility

H2O: 18 mg/mL, DMSO: 6.3 mg/mL

Biochem/physiol Actions

Histidine decarboxylase inhibitor.

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
041K4702
011K4706

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G D Prell et al.
Journal of neurochemistry, 66(5), 2153-2159 (1996-05-01)
In mammalian brain, histamine is known to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH), then tele-methylimidazoleacetic acid (t-MIAA). We previously showed that imidazoleacetic acid (IAA), a GABA agonist, and histamine's metabolite in the periphery, is present in
K Sugimoto et al.
Journal of neurochemistry, 65(2), 791-797 (1995-08-01)
The mast cell-deficient [Ws/Ws (White spotting in the skin)] rat was investigated with regard to the origin of histamine in the brain. No mast cells were detected in the pia mater and the perivascular region of the thalamus of Ws/Ws
Long-term depletion of brain histamine induced by α-fluoromethylhistidine increases feeding-associated locomotor activity in mice with a modulation of brain amino acid levels.
Sakai, et al.
Behavioural Brain Research, 14, 83-88 (1995)

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