推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
~48 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using human HEK-293K cells
western blot: 0.5-1 μg/mL using whole extract of mouse lung
western blot: 1-2 μg/mL using whole extract of rat lung
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FLOT1(10211)
mouse ... Flot1(14251)
rat ... Flot1(64665)
一般描述
Flotillin 1（FLOT1）也称为reggie-2，是一种雌激素反应性基因，位于人类染色体6p21.33。该基因编码整合膜蛋白和脂筏的成分。
Flotillin 是脂筏（lipid raft）相关蛋白，主要在脂肪组织、条纹肌肉组织和肺中表达。 它在多种细胞过程（如吞噬、胞吞、胰岛素信号传导和神经元再生）中起关键作用。抗flotillin 1 抗体可用于免疫印迹和免疫定位。兔抗flotillin 1抗体与大鼠、小鼠和人的flotillin 1 发生特异反应。
免疫原
对应于小鼠脂筏标记蛋白 1 的氨基酸残基 413-428 的合成肽，N-端添加了半胱氨酸，与 KLH 偶联。与大鼠中的相应序列相同，与人的相应序列相差 1 个氨基酸。
应用
兔抗-脂筏标记蛋白 1 抗体可用于免疫印迹分析。
抗脂筏标记蛋白 1 抗体可用于免疫荧光和蛋白质印迹。
生化/生理作用
Flotillin 1（(FLOT1）在胞吞作用中起一定作用。它也在生长因子信号传导中起作用，并激活丝裂原活化蛋白激酶信号传导。此外，它还参与吞噬作用以及肌动蛋白细胞骨架和膜转运的调节。该蛋白还与肿瘤进展有关，在许多癌症（包括乳腺癌）中表达。
目标描述
脂筏标记蛋白 1 编码与小窝相关的完整膜蛋白。小窝是内在细胞膜上的小区域，参与囊泡运输和信号转导。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
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