推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~48 kDa
种属反应性
rat, mouse, human
浓度
~1 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using human HEK-293K cells
western blot: 0.5-1 μg/mL using whole extract of mouse lung
western blot: 1-2 μg/mL using whole extract of rat lung
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FLOT1(10211)
mouse ... Flot1(14251)
rat ... Flot1(64665)
一般描述
Flotillin 1(FLOT1)也称为reggie-2,是一种雌激素反应性基因,位于人类染色体6p21.33。该基因编码整合膜蛋白和脂筏的成分。
Flotillin 是脂筏(lipid raft)相关蛋白,主要在脂肪组织、条纹肌肉组织和肺中表达。 它在多种细胞过程(如吞噬、胞吞、胰岛素信号传导和神经元再生)中起关键作用。抗flotillin 1 抗体可用于免疫印迹和免疫定位。兔抗flotillin 1抗体与大鼠、小鼠和人的flotillin 1 发生特异反应。
免疫原
对应于小鼠脂筏标记蛋白 1 的氨基酸残基 413-428 的合成肽,N-端添加了半胱氨酸,与 KLH 偶联。与大鼠中的相应序列相同,与人的相应序列相差 1 个氨基酸。
应用
兔抗-脂筏标记蛋白 1 抗体可用于免疫印迹分析。
抗脂筏标记蛋白 1 抗体可用于免疫荧光和蛋白质印迹。
生化/生理作用
Flotillin 1((FLOT1)在胞吞作用中起一定作用。它也在生长因子信号传导中起作用,并激活丝裂原活化蛋白激酶信号传导。此外,它还参与吞噬作用以及肌动蛋白细胞骨架和膜转运的调节。该蛋白还与肿瘤进展有关,在许多癌症(包括乳腺癌)中表达。
目标描述
脂筏标记蛋白 1 编码与小窝相关的完整膜蛋白。小窝是内在细胞膜上的小区域,参与囊泡运输和信号转导。
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Pain, 162(1), 243-252 (2020-10-04)
Global spread of severe acute respiratory syndrome coronavirus 2 continues unabated. Binding of severe acute respiratory syndrome coronavirus 2's spike protein to host angiotensin-converting enzyme 2 triggers viral entry, but other proteins may participate, including the neuropilin-1 receptor (NRP-1). Because
International journal of molecular sciences, 23(15) (2022-08-13)
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are associated with obesity. They are accompanied by increased levels of free cholesterol in the liver. Most free cholesterol resides within the plasma membrane. We assessed the impact of adding or
Journal of cellular physiology, 226(10), 2651-2665 (2011-07-28)
Mammalian spermatozoa attain the ability to fertilize an oocyte as they negotiate the female reproductive tract. This acquisition of functional competence is preceded by an intricate cascade of biochemical and functional changes collectively known as "capacitation." Among the universal correlates
bioRxiv : the preprint server for biology (2020-09-02)
Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2's Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and
Cells, 11(11) (2022-06-11)
Fabry disease (FD) is a rare life-threatening disorder caused by deficiency of the alpha-galactosidase A (GLA) enzyme with a characteristic pain phenotype. Impaired GLA production or function leads to the accumulation of the cell membrane compound globotriaosylceramide (Gb3) in the
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